| Tag | Content |
|---|---|
| Uniprot ID | D4A3W9 |
| Entrez ID | 316526 |
| Genbank protein ID | EDL75370.1 |
| Genbank nucleotide ID | NM_001108226.1 |
| Ensembl protein ID | ENSRNOP00000023439 |
| Ensembl nucleotide ID | ENSRNOG00000017409 |
| Gene name | Protein Wnt |
| Gene symbol | Wnt6 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Ligand for members of the frizzled family of seven transmembrane receptors. |
| Sequence | MLPPVPSCLG LLLLLLLCPA HVGGLWWAVG SPLVMDPTSI CRKARRLAGR QAELCQAEPE 60 VVAELARGAR LGVRECQFQF RFRRWNCSSH SKAFGRVLQQ DIRETAFVFA ITAAGASHAV 120 TQACSMGELL QCGCQAPRGR APPRPSGLLG TPGPPGPTGS PDASAAWEWG GCGDDVDFGD 180 EKSRLFMDAQ HKRGRGDIRA LVQLHNNEAG RLAVRSHTRT ECKCHGLSGS CALRTCWQKL 240 PPFREVGARL LERFHGASRV MGTNDGKALL PAVRTLKPPG RADLLYAADS PDFCAPNRRT 300 GSPGTRGRAC NSSAPDLSGC DLLCCGRGHR QESVQLEENC LCRFHWCCVV QCHRCRVRKE 360 LSLCL 365 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WNT6 | 505075 | F1MN70 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | WNT6 | A0A452FTD5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | WNT6 | 7475 | Q9Y6F9 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Wnt6 | 22420 | P22727 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | WNT6 | 742467 | A0A2I3SR43 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WNT6 | A0A287BRH3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WNT6 | G1TQH3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Wnt6 | 316526 | D4A3W9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | wnt6b | F1RAB5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0005109 | frizzled binding |
| GO:0009798 | axis specification |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0045165 | cell fate commitment |
| GO:0060684 | epithelial-mesenchymal cell signaling |
| GO:0072080 | nephron tubule development |
| GO:0072079 | nephron tubule formation |
| GO:0030182 | neuron differentiation |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0010628 | positive regulation of gene expression |
| GO:0070172 | positive regulation of tooth mineralization |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0016055 | Wnt signaling pathway |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00246 | WNT1 |
| Pfam ID | Pfam Term |
|---|---|
| PF00110 | wnt |