| Tag | Content |
|---|---|
| Uniprot ID | P22727; Q80ZM9; |
| Entrez ID | 22420 |
| Genbank protein ID | AAA40569.1; BAE21949.1; AAH48700.1; EDL00351.1; |
| Genbank nucleotide ID | NM_009526.3; XM_006495887.3; XM_006495888.3; |
| Ensembl protein ID | ENSMUSP00000006716 |
| Ensembl nucleotide ID | ENSMUSG00000033227 |
| Gene name | Protein Wnt-6 |
| Gene symbol | Wnt6 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | E14.5 |
| Data sources | Homology search |
| Reference | |
| Functional description | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. |
| Sequence | MLPPVPSRLG LLLLLLCPAH VDGLWWAVGS PLVMDPTSIC RKARRLAGRQ AELCQAEPEV 60 VAELARGARL GVRECQFQFR FRRWNCSSHS KAFGRVLQQD IRETAFVFAI TAAGASHAVT 120 QACSMGELLQ CGCQAPRGRA PPRPSGLLGT PGPPGPTGSP DASAAWEWGG CGDDVDFGDE 180 KSRLFMDAQH KRGRGDIRAL VQLHNNEAGR LAVRSHTRTE CKCHGLSGSC ALRTCWQKLP 240 PFREVGARLL ERFHGASRVM GTNDGKALLP AVRTLKPPGR ADLLYAADSP DFCAPNRRTG 300 SPGTRGRACN SSAPDLSGCD LLCCGRGHRQ ESVQLEENCL CRFHWCCVVQ CHRCRVRKEL 360 SLCL 364 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WNT6 | 505075 | F1MN70 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | WNT6 | A0A452FTD5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | WNT6 | 7475 | Q9Y6F9 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Wnt6 | 22420 | P22727 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | WNT6 | 742467 | A0A2I3SR43 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WNT6 | A0A287BRH3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WNT6 | G1TQH3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Wnt6 | 316526 | D4A3W9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | wnt6b | F1RAB5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005102 | signaling receptor binding | TAS |
| GO:0005109 | frizzled binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001658 | branching involved in ureteric bud morphogenesis | IGI |
| GO:0007165 | signal transduction | TAS |
| GO:0007267 | cell-cell signaling | TAS |
| GO:0009798 | axis specification | IDA |
| GO:0009887 | animal organ morphogenesis | TAS |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0010628 | positive regulation of gene expression | IDA |
| GO:0016055 | Wnt signaling pathway | IDA |
| GO:0016055 | Wnt signaling pathway | IBA |
| GO:0030182 | neuron differentiation | IBA |
| GO:0042475 | odontogenesis of dentin-containing tooth | ISO |
| GO:0045165 | cell fate commitment | IBA |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA |
| GO:0060684 | epithelial-mesenchymal cell signaling | IDA |
| GO:0070172 | positive regulation of tooth mineralization | ISO |
| GO:0072079 | nephron tubule formation | IDA |
| GO:0072080 | nephron tubule development | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | IBA |
| GO:0005788 | endoplasmic reticulum lumen | TAS |
| GO:0009986 | cell surface | IDA |
| GO:0031012 | extracellular matrix | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-3238698 | WNT ligand biogenesis and trafficking | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00246 | WNT1 |
| Pfam ID | Pfam Term |
|---|---|
| PF00110 | wnt |