Gene: WFIKKN1

Basic information

Tag Content
Uniprot ID E1BKQ4
Entrez ID 540233
Genbank protein ID
Genbank nucleotide ID NM_001205796.1
Ensembl protein ID ENSBTAP00000003547
Ensembl nucleotide ID ENSBTAG00000002737
Gene name WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Gene symbol WFIKKN1
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MPALRPLRLL LLLAGLTAGA SLPPGPGGHP GVCPNQLSPN LWVDAQSTCE RECVGDQDCA 60
ATEKCCTNVC GLQSCVAARF PDGGPAASRL AASCEGFVCA QQGSDCDIWD GQPVCRCRDR 120
CEKEPSFTCA SDGLTYYNRC YMDAEACLRG LRLRVVPCKH VLSWPPSSPR PPETTARPTP 180
GDAPVPPALY SSPSPQAVYV GGTASLHCDV SGRPPPAVTW EKQSDQRENL IMRPDQMYGN 240
VVVTSIGQLV LYNARPEDAG LYTCTARNAA GLLRADFPLS VVQRDPAGAG AHEAANAPAQ 300
CLPSTQACVG PPSGRVLWHF DPQRRGCMTF PVGSCAGGAQ GFETYEACQQ ACARDPGDAC 360
ALPAVQGPCQ GWEPRWAYSP LLQHCHPFEY SGCEGNGNNF ESRESCEHAC PVPRTPPCRA 420
CRLRSKLALS LCRSDFAIVG RLTEVLEEPE AGGGGIARVA LDEVLKDDKM GLRLLGTKYL 480
EVTLIGVDRA CPCPNVTAGD GPLVIMGEVR DGVAMLDAGS YVRAASEKRV KKISELLERK 540
ACELLNRFQD

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologWFIKKN1540233E1BKQ4Bos taurusPredictionMore>>
1:1 orthologWFIKKN1102172587A0A452E4Z1Capra hircusPredictionMore>>
1:1 orthologWFIKKN1117166Q96NZ8Homo sapiensPredictionMore>>
1:1 orthologWfikkn1215001Q8R0S6CPOMus musculusPublicationMore>>
1:1 orthologWFIKKN1107968756A0A2I3S3H3Pan troglodytesPredictionMore>>
1:1 orthologWFIKKN1A0A286ZU02Sus scrofaPredictionMore>>
1:1 orthologWfikkn1363555P0C5J5Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005576 extracellular region
GO:0048019 receptor antagonist activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0050431 transforming growth factor beta binding
GO:0048747 muscle fiber development
GO:0043392 negative regulation of DNA binding
GO:0032091 negative regulation of protein binding
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0060021 roof of mouth development
GO:0001501 skeletal system development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR036645 Elafin-like_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR001134 Netrin_domain
IPR020901 Prtase_inh_Kunz-CS
IPR008993 TIMP-like_OB-fold
IPR008197 WAP_dom
IPR033638 WFIKKN1

PROSITE

PROSITE ID PROSITE Term
PS00280 BPTI_KUNITZ_1
PS50279 BPTI_KUNITZ_2
PS50835 IG_LIKE
PS51465 KAZAL_2
PS50189 NTR
PS51390 WAP

Pfam

Pfam ID Pfam Term
PF00014 Kunitz_BPTI
PF00095 WAP