| Tag | Content |
|---|---|
| Uniprot ID | E1BKQ4 |
| Entrez ID | 540233 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001205796.1 |
| Ensembl protein ID | ENSBTAP00000003547 |
| Ensembl nucleotide ID | ENSBTAG00000002737 |
| Gene name | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 |
| Gene symbol | WFIKKN1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPALRPLRLL LLLAGLTAGA SLPPGPGGHP GVCPNQLSPN LWVDAQSTCE RECVGDQDCA 60 ATEKCCTNVC GLQSCVAARF PDGGPAASRL AASCEGFVCA QQGSDCDIWD GQPVCRCRDR 120 CEKEPSFTCA SDGLTYYNRC YMDAEACLRG LRLRVVPCKH VLSWPPSSPR PPETTARPTP 180 GDAPVPPALY SSPSPQAVYV GGTASLHCDV SGRPPPAVTW EKQSDQRENL IMRPDQMYGN 240 VVVTSIGQLV LYNARPEDAG LYTCTARNAA GLLRADFPLS VVQRDPAGAG AHEAANAPAQ 300 CLPSTQACVG PPSGRVLWHF DPQRRGCMTF PVGSCAGGAQ GFETYEACQQ ACARDPGDAC 360 ALPAVQGPCQ GWEPRWAYSP LLQHCHPFEY SGCEGNGNNF ESRESCEHAC PVPRTPPCRA 420 CRLRSKLALS LCRSDFAIVG RLTEVLEEPE AGGGGIARVA LDEVLKDDKM GLRLLGTKYL 480 EVTLIGVDRA CPCPNVTAGD GPLVIMGEVR DGVAMLDAGS YVRAASEKRV KKISELLERK 540 ACELLNRFQD |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WFIKKN1 | 540233 | E1BKQ4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN1 | 102172587 | A0A452E4Z1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN1 | 117166 | Q96NZ8 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn1 | 215001 | Q8R0S6 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | WFIKKN1 | 107968756 | A0A2I3S3H3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN1 | A0A286ZU02 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Wfikkn1 | 363555 | P0C5J5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005576 | extracellular region |
| GO:0048019 | receptor antagonist activity |
| GO:0004867 | serine-type endopeptidase inhibitor activity |
| GO:0050431 | transforming growth factor beta binding |
| GO:0048747 | muscle fiber development |
| GO:0043392 | negative regulation of DNA binding |
| GO:0032091 | negative regulation of protein binding |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0001501 | skeletal system development |
| InterPro ID | InterPro Term |
|---|---|
| IPR036645 | Elafin-like_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR002350 | Kazal_dom |
| IPR036058 | Kazal_dom_sf |
| IPR002223 | Kunitz_BPTI |
| IPR036880 | Kunitz_BPTI_sf |
| IPR001134 | Netrin_domain |
| IPR020901 | Prtase_inh_Kunz-CS |
| IPR008993 | TIMP-like_OB-fold |
| IPR008197 | WAP_dom |
| IPR033638 | WFIKKN1 |