| Tag | Content |
|---|---|
| Uniprot ID | P0C5J5 |
| Entrez ID | 363555 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001129776.1 |
| Ensembl protein ID | ENSRNOP00000056900 |
| Ensembl nucleotide ID | ENSRNOG00000021578 |
| Gene name | WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 |
| Gene symbol | Wfikkn1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). |
| Sequence | MPAPQPLLPL LFAFVLIHLT SETNLLPEPG SHPGMCPNQL SPHLWVDAQS TCERECTRDQ 60 DCAASEKCCT NVCGLQSCVA ARFPSGGPAT PETAASCEDF QCPQQGSNCD IWDGQPVCRC 120 RDRCEKEPSF TCASDGLTYY NRCYMDAEAC LRGLHLHVVP CKHILSWPPS SPGPPETTAR 180 PTPGAAPMPP ALYNSPSPQA VHVGGTASLH CDVSGRPPPA VTWEKQSHQR ENLIMRPDQM 240 YGNVVVTSIG QLVLYNAQLE DAGLYTCTAR NAAGLLRADF PLSVLQRATT QDRDPGVLAL 300 AECQPDTQAC VGPPTPHHVL WRFDPQRGSC MTFPALKCDG AARGFETYEA CQQACVRGPG 360 DVCALPPVQG PCQGWEPRWA YSPLLQQCHP FIYSGCEGNS NNFESRESCE DACPVPRTPP 420 CRACRLKSKL ALSLCRSDFA IVGRLTEVLE EPEAAGGIAR VALDDVLKDD KMGLKFLGTK 480 YLEVTLSGMD WACPCPNVTV GDGPLVIMGE VREGVAVLDA NSYVRAASEK RVKKIVELLE 540 KKACELLNRF QD 552 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WFIKKN1 | 540233 | E1BKQ4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN1 | 102172587 | A0A452E4Z1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN1 | 117166 | Q96NZ8 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn1 | 215001 | Q8R0S6 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | WFIKKN1 | 107968756 | A0A2I3S3H3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN1 | A0A286ZU02 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Wfikkn1 | 363555 | P0C5J5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005576 | extracellular region |
| GO:0008191 | metalloendopeptidase inhibitor activity |
| GO:0048019 | receptor antagonist activity |
| GO:0004867 | serine-type endopeptidase inhibitor activity |
| GO:0050431 | transforming growth factor beta binding |
| GO:0048747 | muscle fiber development |
| GO:0043392 | negative regulation of DNA binding |
| GO:0032091 | negative regulation of protein binding |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0001501 | skeletal system development |
| InterPro ID | InterPro Term |
|---|---|
| IPR036645 | Elafin-like_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR002350 | Kazal_dom |
| IPR036058 | Kazal_dom_sf |
| IPR002223 | Kunitz_BPTI |
| IPR036880 | Kunitz_BPTI_sf |
| IPR001134 | Netrin_domain |
| IPR020901 | Prtase_inh_Kunz-CS |
| IPR008993 | TIMP-like_OB-fold |
| IPR008197 | WAP_dom |
| IPR033638 | WFIKKN1 |