| Tag | Content |
|---|---|
| Uniprot ID | Q8R0S6 |
| Entrez ID | 215001 |
| Genbank protein ID | AAH26460.1 |
| Genbank nucleotide ID | NM_001100454.1 |
| Ensembl protein ID | ENSMUSP00000135083 |
| Ensembl nucleotide ID | ENSMUSG00000071192 |
| Gene name | WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 |
| Gene symbol | Wfikkn1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 24019467 |
| Functional description | Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). |
| Sequence | MPAPQPFLPL LFVFVLIHLT SETNLLPDPG SHPGMCPNEL SPHLWVDAQS TCERECTGDQ 60 DCAASEKCCT NVCGLQSCVA ARFPSGGPAV PETAASCEGF QCPQQGSDCD IWDGQPVCRC 120 RDRCEKEPSF TCASDGLTYY NRCYMDAEAC LRGLHLHVVP CKHILSWPPS SPGPPETTAR 180 PTPGAAPMPP ALYNSPSPQA VHVGGTASLH CDVSGRPPPA VTWEKQSHQR ENLIMRPDQM 240 YGNVVVTSIG QLVLYNAQLE DAGLYTCTAR NAAGLLRADF PLSVLQRATT QDRDPGIPAL 300 AECQADTQAC VGPPTPHHVL WRFDPQRGSC MTFPALRCDG AARGFETYEA CQQACVRGPG 360 DVCALPAVQG PCQGWEPRWA YSPLLQQCHP FVYSGCEGNS NNFETRESCE DACPVPRTPP 420 CRACRLKSKL ALSLCRSDFA IVGRLTEVLE EPEAAGGIAR VALDDVLKDD KMGLKFLGTK 480 YLEVTLSGMD WACPCPNVTA VDGPLVIMGE VREGVAVLDA NSYVRAASEK RVKKIVELLE 540 KKACELLNRF QD 552 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WFIKKN1 | 540233 | E1BKQ4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN1 | 102172587 | A0A452E4Z1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN1 | 117166 | Q96NZ8 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn1 | 215001 | Q8R0S6 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | WFIKKN1 | 107968756 | A0A2I3S3H3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN1 | A0A286ZU02 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Wfikkn1 | 363555 | P0C5J5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0008191 | metalloendopeptidase inhibitor activity | IEA |
| GO:0048019 | receptor antagonist activity | ISO |
| GO:0048019 | receptor antagonist activity | IBA |
| GO:0050431 | transforming growth factor beta binding | ISO |
| GO:0050431 | transforming growth factor beta binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001501 | skeletal system development | IGI |
| GO:0010951 | negative regulation of endopeptidase activity | IEA |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | ISO |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | IBA |
| GO:0032091 | negative regulation of protein binding | IDA |
| GO:0043392 | negative regulation of DNA binding | IDA |
| GO:0045861 | negative regulation of proteolysis | ISO |
| GO:0048747 | muscle fiber development | IMP |
| GO:0060021 | roof of mouth development | IGI |
| GO:2000272 | negative regulation of signaling receptor activity | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| InterPro ID | InterPro Term |
|---|---|
| IPR036645 | Elafin-like_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR002350 | Kazal_dom |
| IPR036058 | Kazal_dom_sf |
| IPR002223 | Kunitz_BPTI |
| IPR036880 | Kunitz_BPTI_sf |
| IPR001134 | Netrin_domain |
| IPR020901 | Prtase_inh_Kunz-CS |
| IPR008993 | TIMP-like_OB-fold |
| IPR008197 | WAP_dom |
| IPR033638 | WFIKKN1 |