| Tag | Content |
|---|---|
| Uniprot ID | E2R5C8 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCAFP00000017360 |
| Ensembl nucleotide ID | ENSCAFG00000011805 |
| Gene name | Sterol-C5-desaturase |
| Gene symbol | SC5D |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPPAADWLAA PPLGARARPR PPALPARPPP SGPAACDPAD AEWAARSGGA KMDLVLSAAD 60 YYFFTPYIYP ASWSEDDIFR QTISLLIVTN LGAYILYFFF ATLSYYFVYD HSLMKHPQFL 120 KNQVYREIMF TVQSLPWISI PTVLLFLLEL RGYSKLYDDI GEFPSGWFRL IISILSFLFF 180 TDMLIYWIHR GLHHRLVYKR IHKPHHLWKI PTPFASHAFH PVDGFLQSLP YHIYPFIFPL 240 HKVVYLSLYI LVNIWTISIH DGDFRVPQIL RPFINGSAHH TDHHMFFDYN YGQYFTLWDR 300 IGGSFKNPSS FEGKGPLSYV KKMTEEKCNT HTKNGCKNEK LFSGELTKTE |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SC5D | 525154 | Q3SYX8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SC5D | E2R5C8 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | SC5D | A0A452DVT9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SC5D | 100063543 | F6PHM2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SC5D | 6309 | O75845 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sc5d | 235293 | O88822 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SC5D | 451624 | A0A2J8N215 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 100520925 | A0A4X1VKK3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Sc5d | 114100 | Q9EQS5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | sc5d | F1QG97 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0016021 | integral component of membrane |
| GO:0016020 | membrane |
| GO:0000248 | C-5 sterol desaturase activity |
| GO:0005506 | iron ion binding |
| GO:0016491 | oxidoreductase activity |
| GO:0033490 | cholesterol biosynthetic process via lathosterol |
| GO:0016126 | sterol biosynthetic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR006694 | Fatty_acid_hydroxylase |
| Pfam ID | Pfam Term |
|---|---|
| PF04116 | FA_hydroxylase |