| Tag | Content |
|---|---|
| Uniprot ID | Q9EQS5 |
| Entrez ID | 114100 |
| Genbank protein ID | EDL95251.1; AAH81704.1; BAB19798.1; |
| Genbank nucleotide ID | NM_053642.2; XM_017595406.1; |
| Ensembl protein ID | ENSRNOP00000011284 |
| Ensembl nucleotide ID | ENSRNOG00000008305 |
| Gene name | Lathosterol oxidase |
| Gene symbol | Sc5d |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol in cholesterol biosynthesis. |
| Sequence | MDLVLSAADY YFFTPYVYPA TWPEDNIIRQ TVSLLVVTNL GAYILYFFCA TLSYYFVYDH 60 SLMKHPQFLK NQVSREIMFT VKSLPWISIP TVSLFLLELR GYSKLYDDIG DFPNGWIHLI 120 MSVISFLFFT DMLIYWIHRG LHHRLLYKHI HKPHHIWKIP TPFASHAFHP VDGFLQSLPY 180 HIYPFVFPLH KVVYLGLYVL VNVWTISIHD GDFRVPQIFR PFINGSAHHT DHHMLFDYNY 240 GQYFTLWDRI GGSFKHPSSF EGKGPHSYVK NMTEKESNSL AENGCKSKKL CNGEFTKNE 299 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SC5D | 525154 | Q3SYX8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SC5D | E2R5C8 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | SC5D | A0A452DVT9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SC5D | 100063543 | F6PHM2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SC5D | 6309 | O75845 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sc5d | 235293 | O88822 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SC5D | 451624 | A0A2J8N215 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 100520925 | A0A4X1VKK3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Sc5d | 114100 | Q9EQS5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | sc5d | F1QG97 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0016021 | integral component of membrane |
| GO:0043231 | intracellular membrane-bounded organelle |
| GO:0016020 | membrane |
| GO:0000248 | C-5 sterol desaturase activity |
| GO:0005506 | iron ion binding |
| GO:0050046 | lathosterol oxidase activity |
| GO:0016491 | oxidoreductase activity |
| GO:0033490 | cholesterol biosynthetic process via lathosterol |
| GO:0006631 | fatty acid metabolic process |
| GO:0016126 | sterol biosynthetic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0256 | Endoplasmic reticulum |
| KW-0408 | Iron |
| KW-0444 | Lipid biosynthesis |
| KW-0443 | Lipid metabolism |
| KW-0472 | Membrane |
| KW-0560 | Oxidoreductase |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0752 | Steroid biosynthesis |
| KW-0753 | Steroid metabolism |
| KW-0756 | Sterol biosynthesis |
| KW-1207 | Sterol metabolism |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| InterPro ID | InterPro Term |
|---|---|
| IPR006694 | Fatty_acid_hydroxylase |
| Pfam ID | Pfam Term |
|---|---|
| PF04116 | FA_hydroxylase |