| Tag | Content |
|---|---|
| Uniprot ID | F1Q633 |
| Entrez ID | 563428 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001130840.1 |
| Ensembl protein ID | ENSDARP00000071316 |
| Ensembl nucleotide ID | ENSDARG00000054619 |
| Gene name | Fraser extracellular matrix complex subunit 1 |
| Gene symbol | fras1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPSDTEERPP RETQSPPPAY VVRWSLPFSA DPGSNNTSWK PDTCQDCICY NDIVICKPTR 60 CRNPQCDFPR GERLRIPPNK CCPECFAPSP GICHHEGLVY GHDSQWSNSK CSVCTCAHGK 120 VTCGPRACPP LSCGKDQSPF IPDGNCCPVC AHNGVSCSWE GREYRDGLEW TSSPCTKCRC 180 RNGHTECLVA ECQPVTCKVN ENLVVHPGQC CPQCEPNPCM EAGNEYKHGE QWQRSSCTTC 240 VCDRGHSRCQ TEKCPPLHCD KGQTKVKRAD QCCEDCATSK GSCLYEGIVR YHGDMWNGTG 300 CEFCMCERGQ VLCQRVECSR SECPRKNWSI CLESAAQSNL EIVREGLCRE CQCQEGHVTC 360 YQHSCPTCPL GTLTIPHREQ CCPDCNPEVK CHEDCLTCSG TPDHCASCRD PSALLMNGRC 420 LQACPQGFFA QGKVCAACQP SCATCENDFE CTACGGSFLL SGRQCVATCE RGLFQAHTHC 480 LSCHDLCSSC QGAGPQDCLT CSDSSHLLKD GYCVSDCGPG FYTSQGNSCD PSCATCQPDS 540 PSCMSCPAEH ALHQGKCAPQ CPAQYYKDDH GRCQACHSSC ASCSGPAVSH CTSCSKALIL 600 NQGQCVESCG EGLFSRAGHC HSCHSSCRVC VGPDSSDCTQ CVKMEEVLQP QNGHVSHGSC 660 MSACRPQHYL ETDRTCRECH SSCSGCIGGS FQNCTSCLRP GVLHQGQCLS KCPNGFFHIQ 720 DLTSCHPSCK ECTGTSQADC SACPAHASLH NGYCRTSCPE GQYLNSVGFC DECEEGCQRC 780 VADLQSGSGT VCLWCKVPRM LLLGNHCVPE CPHKHYRWHG ACKKCHSSCE ECSADGPLSC 840 TSCLAPEVLA PSGLCSPRCP TGYYADENRV CQKCDSQCLS CEMAGVCSSC RDPAKVLLFG 900 ECQYESCAHQ YYLNTSTRTC RECDWSCNAC RGPLRSDCLQ CMEGYVLQDG ICVPGCSPGF 960 YQDAERCLSC EEHCEQCQAH GQCQRCQLPY ASFNGHCVLE CRKHYFLDDS TRQCTACSAG 1020 CVECVSAGEC RVCAENTFLK DGRCIPDCGH GYYADLKTRA CHANSRAPSL YINGSLLVPI 1080 GGVKPLDPAL LSIKDADSQS ESMLLQLLQP PSNGHLRLLE NDRERSLGKD DTFTYTQLKR 1140 RAVRFIHDKE QTKSGQFTLR AADPQLFSQP QTVTVQALSQ QPPTVITNQI LYINSGETAV 1200 ISRSILHISD LDNPQDVFIT VLDPPQHGRL TYMHSDTQVT HFKLEELDGE QLQYVHDRSD 1260 GDQDRLLLQV NDGHSYQNVL FHISIEQKVG LTPHLRSVPK TWVKEGGMVQ LSKKCLNAQF 1320 KGASDSEILY SIHSESGQPK YGEIVLVSMP ADGPVEAWQA FSDGQDSTPT SSFTQQDVNE 1380 GTVWYRHYGS GTQRDTFQFQ VSSEIYPETL SDTQTFTIGV MPQSPGMPQL SPGVDLQITA 1440 LEDRVTVISP SALSFTDSET PSDKLVYNIT KALTSGHGVL EHKDRPYHHV RLFTQADVDS 1500 GKIIYRPPQA PSHLQELYQY SFTGLPESVS VHFTVSGGEH TTPEMDFAIL LLVNHQQPPV 1560 FQILDPVLEV SLGGRAPVGV QQLAVTDSDT APEELEFEVV EGPLHGTLLK VDLGSQVQMV 1620 NGDTFTSSDV TRNILQYEHA GLTTEEDSMT FSVTDGISMT SIAVQVLVSE VKGDAPKRDP 1680 KAFLSMEVAE KSSSIIRRSH LAYMDDASPD ERIFVQLVSV PMYGILTKNK AGADYEELSE 1740 YSSFTMEDIN NHKIRYVTSF ETGNQPVTDI FHFVVYDGDN NRLENQMFTI TITTTQRQPP 1800 VVSVRSGIKV QEGGRVQLST NHIIASDPDT PRKDLLVWLI RPPKFGFIEN TKQAVVGESR 1860 VISTDVPFTI EDLNSDHIFY VQNIRQSNIR QDVFSFYISD GSSQTEAFDV TIDIQHTKED 1920 LVPIISVNSI HVEENSGVVI TNSSLNVLDR DTPENELLLT IIKKPSYGKI RRRQFYSDPL 1980 ENGRILQQGS TFTYQDILDE LLVYTPDGRG SGTDEIQFSV TDGIYTETGR LEFSMDIRKK 2040 EGPRVTINRG LQLAAGSSSK ITEQHLKGTD IDSDNLKLRF TLIKDLSVGS LMLKTGRNKA 2100 RVSVKGPVTS FTQDDINKGH VEYIHEKGES GGSFSFKFNL EDPEGNRVID QSFFISVLED 2160 RLPPTVVVNK GLVLDENSLK KITTLQLSST DQDSEPDELV YRITKQPQLG HLEHSNKPGT 2220 RISSFTQADL ASRSIQYVHT SEDEIHSDDF TFTVSDGGNE VSQTFYITIR PVDDALPVLQ 2280 VPGMRVQEGV RKTITEFELK ATDADTEEDS VTFTIVQAPR HGTIERTSNG QHYRQTNTFT 2340 MDDVYQNRIS YNHDGSNSLK DRFTFTVGDG TNMFFIIEEG GKEVVTAAPQ KFKIDILPVD 2400 DGTPRIVTNL GLQWLEYMEN KATNLISKKE LFTIDPDTDD GQLTYEITTE AKHGYLESKL 2460 NPGKPITSFT QADINLGLIR YVLSEDNVQE TMDNFKFLVK DSKPNIVSDN VFHIQWSLIS 2520 FEHKSFNVSE KDGTVAVTVK RTGNLNQYAI VLCRTEQGTA TSTSSMGSRA GQQDYVEYAG 2580 QVQFDEREDT KVCTIVINDD QVFENIESFN VELSMPVYAL LGSVTRAKVN INDTEDEPTL 2640 QFDKKTYHVN ESTGFIFAPV ERKGDTSSTV SALCYTVPKS ARGSSLHALE SGSDYKTRGM 2700 SGDNRLIFGP GVSMSTCDVK LIDDSEYELS EEFELVLSDA SDNARMGDVT VAKVIIDGPN 2760 DASTVFLGNA SYTFSEDAGT IEIPVLRQGS DLSSVTSVWC ATRPAEQDSA TPGVDYIPSS 2820 KKVEFKPGKT EETCSLTIMD DIQNPTIEGK ESFIVFLSSA NGAVLTEPYE ASVYITDTTQ 2880 DIPSMQFDKL AYTVKEKDGV LHIPIFRTGD LSYKSSVRCF TRTMSAMVMD DFEERRNADD 2940 SRITFQKGEK VKNCTVLIQD DSVFEPEEEF QVHLGSPQGD HWIGAMIGVN DIVTVTITND 3000 EDAPTIEFEQ ATYQVREPPG PDGIEVLNIK VIRKGDLDRT SKIRCSTRDG SAQSGVDYNP 3060 KSRVLKYSPG VDHIMFKVEI LSNEDREWHE SFSLVLGPDD PVEAVLGEII IATVTILDQE 3120 AAGSLILPAP PIVVSLSDYD YVQEVTKEGS KKSPSPGYPL VCVTPCDPHY PKYSVMKERC 3180 EEAGINQTSL HFSWEVATPT DTSGARSPFE TVTDNTPYTT INHMVLDSIY FSRRFHVRCV 3240 AQARDKAGHL GTPLRSNIVT IGTEGSICHT PVTTGTARGF QAQSFIATLK YLDVKHKEHP 3300 NRIHISVQIP HQDGMLPLVS TMPLHNLHFL LSESIYRQQH VCSNLVTLKD LQGISETGFL 3360 DDVSYDSISL GPGYDRPYQF NPNVREPRTI QLYKHLNLKS CIWTFDAYYD MTELIDVCGG 3420 SVTADFQVRD SAQSFLTVQV PLYVSYIYVT APRGWASLEH HTEMEFSFFY DTVLWRTGIQ 3480 TDSVLSARLQ IIRIFIKDDG RLVIEFKTHA KFRGQFVPEH HTLPGQKSHL MAPDHLGGME 3540 FDLQLVWSAQ SFDSPYQLWR ATSSYSRKDY SGEYTVFLIP CTVQPTQAWV DSGDKPLSCT 3600 AHAPEKFLLP IAFQQTNRPV PVVYSLNTEF QLCNNEKVFL MDPALADMSV AEMDYKGAFS 3660 MGQTLYGRVL WNPDQNLNSA YKLQLEKVYL CTGRDGYVPF FDPTGTLYNE GPQYGCIQPN 3720 KHLKHRFLLL DRKQPDVCDR YFHDVPFEAS FASDIPDLLS LSAMPGVDGF TMKVDALYKV 3780 EAGHQWYLQV IYVIGPESIS SPRIQRSVTY ELKRSRRDLV DRSGRLMLDE SLIYDNEGDQ 3840 VKNGTNMKTL KLEMEPSGTF NPQMGGSIGG GVAAILLLFL VLLAFCFMVR KCRRVVKKRP 3900 SKTVEDYPLN TKVEVCIERL EKNLNSKHCS VRNINVLNKN PDTYKVNGVK VKQVNLEVKL 3960 HNNLNDGTEV |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FRAS1 | 478446 | J9P6T8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FRAS1 | A0A452G0M2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FRAS1 | 80144 | Q86XX4 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fras1 | 231470 | Q80T14 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | FRAS1 | 461226 | H2R4C8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Fras1 | F1M3H3 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | fras1 | 563428 | F1Q633 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0071711 | basement membrane organization |
| GO:0007154 | cell communication |
| GO:0048703 | embryonic viscerocranium morphogenesis |
| GO:0007492 | endoderm development |
| GO:0010669 | epithelial structure maintenance |
| GO:0033333 | fin development |
| GO:0033334 | fin morphogenesis |