| Tag | Content |
|---|---|
| Uniprot ID | J9P6T8 |
| Entrez ID | 478446 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005639100.2 |
| Ensembl protein ID | ENSCAFP00000041371 |
| Ensembl nucleotide ID | ENSCAFG00000008752 |
| Gene name | Fraser extracellular matrix complex subunit 1 |
| Gene symbol | FRAS1 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGAFRVWLGV ALALAGFAAS PRHCEGACVY QGSLLADATT WKPDSCQNCH CHGNIVICKP 60 AVCRNPQCVF EKGEVLQIAA NQCCPECVLQ TPGSCHHEKK IYAHGTEWAY PPCSVCSCTH 120 GEVRCTPQPC PPLSCGPQEL ESIPEGSCCP VCVGPGKSCS YEGRVFQDGE DWPLSRCAKC 180 VCRNGVTQCF IAHCQPLFCN EDEAIVRVPG KCCPQCSSQS CSASGQVYEH GEQWTENACT 240 TCICDQGEVR CHRQACPPLR CEKGQRRAHR HGECCEECVS PAGSCSHNGI VRYQDEMWKG 300 SACEFCMCDR GQVTCQTGEC AKVECAQGEE LIHLDGKCCP ECISKNGYCV YEENTEFMSS 360 NASEVKRIPE GEKWEDGPCK VCECRGSQVT CYEPSCPPCP VATLAQVVKG QCCPDCTSVH 420 CHPDCLTCSQ SPEHCDLCQD PTKLLQNGQC VHSCGLGFYQ AGALCLACQP QCFTCTSGLE 480 CSSCQPPLLM RHGQCVSTCG DGFYQDRYSC AVCHESCTAC WGPTAKHCMG CRDPLQVLRE 540 GSCESSCGVG FYNKQGICSA CDQSCKSCGP NSPRCLTCAE KTVLHDGKCI AECPGGYYAE 600 ATGRCKVCHN SCASCSGPTG SHCTACIQPQ ALRQGHCLSS CGEGFYPDHG VCKACHSSCL 660 TCVGPEPSHC AQCRKPDEGL QVEHLSGANI TSGECLPQCR AQFYLENTGL CEACHQSCFR 720 CAGKSPHNCT ACWPSQVLLD GQCLSQCPDR YFNQEGSCTE CHPTCRQCHG PSESDCISCH 780 PHVTLAGGSC RSSCKEEQFL NLVGYCADCH RLCRRCTAHL HDPGSTCLRC QNARYLLLGD 840 HCVPDCPSGY YAERGACQKC HPSCRTCQST GPFSCTSCDA NFVLSHLGTC TTACFPGHYL 900 DDSHTCQPCD ADCRSCDSQA SCTSCRDPNK VLLFGECQYE SCAPQYFLDF STKICKECDW 960 SCNACSGPLR TDCLQCMDGY VLQDGACVEQ CSPSFYRDLG LCKSCGNHCL RCQGPHECAR 1020 CEGPFLLLEG QCVQECGKGY FADHVNRQCT ACPRACLQCS RQDQCHLCDH GFFLKSGLCI 1080 SNCIPGFSAH SNETCTGKIY TPSLHVNGSL TLAIGSMKPL DFPLLNVQDQ DGRMEDLQFH 1140 VVSTPTNGQL VLSRNGREVQ LDKAGHFSWK DVNEKKVRFV HSKEKPRKGY FSLKISDQQF 1200 YSKPQLINVE AFSTQAPYVL RNEALHISRG ERGTITTQLL DIRDDDNPQD VVVEVLDPPL 1260 HGQLLQILQS PATPIYQFRL DELSRGLLHY AHDGSDSISD VAVLQANDGH SFQNILFHVK 1320 TVPKNDGGLQ LGANSMVWVP EGGMLQITNR ILQAEAPGVS ASEIIYKITQ DHPQFGEVVL 1380 LVEMPADSPA GEGQHLPDGR TATPTSTFTQ QDINEGIVWY RHSGVPAQSD SFSFQVSSAS 1440 DAHTHLENHM FNIAILPQTP EAPKLSLGAS LHMTAREDGL TVIQPHSLSF VNSERPSRKL 1500 IYNITLPLHP NQGIIEHRDQ PHSPIRYFTQ EDINQGKIMY RPPPAAPHLQ EIMAFSFAGL 1560 PELVKFHFTV SDGAHTSPEM VLTIHLLPTD RHLPAFRVTA PRLEVSPGGS ASLGLQLVVR 1620 DPEIAPEELF FELRKPPKHG VLLKYTTEFQ VPMATGDTFT YEDIEKNVLQ YLHDGSSAQE 1680 DSMEITVTDG LAATTVEVKV EVSLSEDQGP QLAAGASLSI TVASKSTAVI TRSHLAYVDD 1740 SSPDPEIWIQ LSSLPMYGAL LRMSGPEVEE LSEVSNFTME DINNQKIRYS AVYETDGNLV 1800 TDGFHFSVSD TDHNHLDNQT FTIMITPVEN PPPVIAFADL ITVDEGGRAP LSFHHFFAAD 1860 DQDNLQGDAI IKLSALPKYG CIENMGTGDH FGPGTTSDLE ASFSIQDVLE NYIYYFQSVH 1920 ESIEPTHDIF SFYVSDGNSR SEIHSINITI ERKNDEPPRM TLQPLGVQLS SGVVISNSSL 1980 SLQDLDTPDN ELVFVLTKKP DHGHLLWRQT ASEPLENGRV LTQGSSFTYQ DILAGLVGYM 2040 PGGPGVAVDE FRFSLTDGLH MDTGRMEIYI ELPTSGTPHL AINQGLWLSA GSVARITEQH 2100 LRVTDTDSDD HQVMYIMRED PGAGRLQMVK RDNLEQISVK GPVRSFTQAD VSQGQVEYSH 2160 RKGESGGSFA FKFDVVDGEG NTLIGQSFSI SVLEDTSPPI ITTNKGLILD ENSVEKITTL 2220 ELSATDQESK PTELIYRITR QPELGHLEHA ASPGIQIRSF TQADLISQNI QYIHSSETEK 2280 HSDAFSFTLS DGSSEVTQTF HITIRPVDDS LPVVQSLGMR VQEGVRKTIT EFELKAVDAD 2340 TEAESVTFTI VQPPRHGTIE RTSSGGHSRH ISTFTMEDIY QNRVSYSHDG SNSLRDRFTF 2400 TVADRTNPFF IIEEGGKEVM TAAPQHFQID ILPVDDGTPR IVTNLGLQWL EYMDGKTTNL 2460 ITKKELLTMD PDTDDQHLVY EITEGPKHGY VESKLQPGKA AATFTQEDVN LGLIRYVLHE 2520 EKIHEIMDSF QFLVKDSKPN VVNDNVFHVQ WSLISFKYTS YNVSEKAGSV SVTVQRSGNL 2580 NQYAIVLCRT EEGTASSSSR VSSQPGQQDY VEYAGQVQFD EREDTKSCTI VINDDDVFEN 2640 VESFTVELSM PAYALLGEFT QAKVIINDSE DEPTLEFDKK TYRVNESAGF LFAPIERKGD 2700 SSSIVSAICY TVPKSAMGSS LYALESGSDF KSRGMSADSR VIFGPGVTMS TCDVMLIDDS 2760 EYEEEEEFEI ALADASDNAR IGRVASAKVL ISGPNDASTV SLGNTAFTVS EDAGTVRIPV 2820 IRHGTDLSTF TSVWCATRPS DPASATPGVD YVPSSRKVEF GPGVTEQYCT LTILDDTQYP 2880 VIEGLETFVV FLSSAQGAEL TKPFQAVIAI NDTFQDVPSM QFAKDLLLVK EKEGVLQVPI 2940 IRSGDLSYES SVRCYTQGHS AHVMEDFEER RNEDFSRITF LKGEKMKNCT VSIHDDSMFE 3000 PEEQFRVYLG HPLGNHWSGA RIGKNNMATI TISNDEDAPT IEFEEAAYQV REPSGPDAVA 3060 LLNIKVIRRG DQNRTSKIRC STRDGSAQSG VDYYPKSRVL KFSPGVDHIF FKVEILSNED 3120 REWHESFSLV LGPDDPVEAV LGDVTTATVT ILDQEAAGSL ILPAPPIVVT LADYDHVEEV 3180 TKEGVKKSPS PGYPLVCVTP CDSHFPKYAI MKERCSEAGI NQTSVQFSWE VATPTDGSGA 3240 RSPFETITDN TPFTSVNHMV LDSIYFSRRF HVRCVAKAVD KVGHVGTPLR SNIVTIGTDS 3300 AICHTPVVAG TARGFQAQSF IATLKYLDVK HKEHPNRIHI SVQIPHQDGM LPLISTMPLH 3360 NLHFLLSESI YRHQHVCSNL VTTRDLRGIS EAGFLNNKVY DSTALGPGYD RPFQFDPSVR 3420 EPKTIQLYKH LNLKSCVWTF DAYYDMTELI DVCGGSVTAD FQVRDSAQSF LTIHVPLYVS 3480 YIYVTAPRGW ASLEHHTEME FSFFYDTVLW RTGIQTDSVL SARLQIIRIY IREDGRLVIE 3540 FKTHAKFRGQ FVMEHHTLPD VKSFILTPDH LGGIEFDLQL LWSAQTFDSP YQLWRATSSY 3600 NRKDYSGEYT IYLIPCTVQP TQPWADPGEK PLACTAHAPE RFLIPIAFQQ TNRPVPVVYS 3660 LNTEFQLCNN EKVFLMDPNT SDMSLAEMDY KGAFSKGQIL YGRVLWNPEQ NLNSAYKLQL 3720 EKVYLCTGKD GYVPFFDPTG TIYNEGPQYG CIQPNKHLKH RFLLLDRSQP EVTDKYFHDV 3780 PFEAHFASEL PDFHVVSSMP GVDGFTLKVD ALYKVEAGHQ WYLQVIYIIG PDTISGPRVQ 3840 RSLTASLRRN RRDLVDPSGR LTLDDSLIYD NEGDQVKNGT NMKSLNLEMQ EPVVAASLSQ 3900 TGASIGSALA AIMLLLLVFL VACFITRKCQ KQRKKPPMED ILEEYPLNTK VDVPKRSMDK 3960 VEKNFNRHYC TVRNVNILSA TGGAYGFKGT NVKKLNLEVR VHNNLQDGTE V 4011 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FRAS1 | 478446 | J9P6T8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FRAS1 | A0A452G0M2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FRAS1 | 80144 | Q86XX4 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fras1 | 231470 | Q80T14 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | FRAS1 | 461226 | H2R4C8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Fras1 | F1M3H3 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | fras1 | 563428 | F1Q633 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005604 | basement membrane |
| GO:0016021 | integral component of membrane |
| GO:0007154 | cell communication |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0003338 | metanephros morphogenesis |
| GO:0002009 | morphogenesis of an epithelium |
| GO:0015031 | protein transport |
| GO:0060021 | roof of mouth development |
| GO:0043588 | skin development |