| Tag | Content |
|---|---|
| Uniprot ID | H2R4C8; A0A2J8PFY4; |
| Entrez ID | 461226 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_517202.5 |
| Ensembl protein ID | ENSPTRP00000046968 |
| Ensembl nucleotide ID | ENSPTRG00000016200 |
| Gene name | Fraser extracellular matrix complex subunit 1 |
| Gene symbol | FRAS1 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGVLKVWLGL ALALAEFAVL PHHSEGACVY QGSLLADATI WKPDSCQSCR CHGDIVICKP 60 AVCRNPQCAF EKGEVLQIAA NQCCPECVLR TPGSCHHEKK IHEHGTEWAS SPCSVCSCNH 120 GEVRCTPQPC PPLSCGHQEL AFIPEGSCCP VCVGPGKPCS YEGHVFQDGE DWRLSRCAKC 180 LCRNGVVQCF TAQCQPLFCN QDETVVRVPG KCCPQCSARS CSAAGQVYEH GEQWSENACT 240 TCICDRGEVR CHKQACLPLR CGKGQSRARH HGQCCEECVS PAGSCSYDGV VRYQDEMWKG 300 SACEFCMCDH GQVTCQTGEC AKVECAQGEE LIHLHGKCCP ECISRNGYCV YEETGEFMSS 360 NASEVKRIPE GEKWEDGPCK VCECRGAQVT CYEPSCPPCP VGTLALEAKG QCCPDCTSVH 420 CHPDCLTCSQ SPDHCDLCQD PTKLLQNGWC VHSCGLGFYQ AGSLCLACQP QCSTCTSGLE 480 CSSCQPPLLM RHGQCVPTCG DGFYQDRHSC AVCHESCAGC WGPTEKHCLA CRDPLHVLRD 540 GGCESSCGKG FYNRQGTCSA CDQSCDSCGP SSPRCLTCTE KTVLHDGKCM SECPGGYYAD 600 ATGRCKVCHN SCASCSGPTA SHCTACSPPK ALRQGHCLPR CGEGFYSDHG VCKACHSSCL 660 ACMGPAPSHC TGCKKPEEGL QVEQLSGAGI PSGECLAQCR AHFYLESTGI CEACHQSCFR 720 CAGKSPHNCT DCGPSHVLLD GQCLSQCPDG YFHQEGSCTE CHPTCRQCHG PLESDCISCY 780 PHISLTNGNC RTSCREEQFL NLVGYCADCH HLCQHCAADL HNTGSICLRC QNAHYLLLGD 840 HCVPDCPSGY YAERGACKKC HFSCRTCQGR GPFSCSSCDT NLVLSHTGTC STTCFPGHYL 900 DDNHVCQPCN THCGSCDSQA SCTSCRDPNK VLLFGECQYE SCAPQYYLDF STNTCKECDW 960 SCSACSGPLK TDCLQCMDGY VLQEGACVEQ CLSSFYQDSG LCKNCDSYCL QCQGPHECTR 1020 CKGPFLLLEA QCVQECGKGY FADHAKHKCT ACPWGCLQCS HRDRCHLCDH GFFLKSGLCV 1080 YNCVPGFSVH TSNETCSGKI HTPSLHVNGS LILPIGSIKP LDFSLLNVQD QEGRVEDLLF 1140 HVVSTPTNGQ LVLSRNGKEV QLDKAGHFSW KDVNEKKVRF VHSKEKLRKG YFFLKISDQQ 1200 FFSEPQLINI QAFSTQAPYV LRNEVLHISR GERATITTQL LDIRDDDNPQ DVVIEIIDPP 1260 LHGQLLQTLQ SPAAPVYQFQ LDELSRGLLH YAHDGSDSTS DVAVLQANDG HSFHNILFQV 1320 KTVPQNDRGL QLVANSMVWV PEGGMLQITN RILQAEAPGA SAEEIIYKIT QDYPQFGEVV 1380 LLVNMPADSP ADEGQHLPDG RTATPTSTFT QQDINEGIVW YRHSGAPAQS DSFRFEVSSA 1440 SNAQTRLESH MFNIAILPQT PEAPKVSLEA SLHMTAREDG LTVIQPHSLS FINSEKPSGQ 1500 IVYNITLPLH PNQGIIEHRD HPHSPIWYFT QEDINQGKVM YRPPLAAPHL QELMAFSFAG 1560 LPESVKFHFT VSDGEHTSPE MVLTIHLLPS DQQLPVFQVT ASRLAVSPGG STSVGLQVVV 1620 RDAETAPKEL FFELRRPPQH GVLLKHTAEF RRPMATGDTF TYEDVEKNAL QYIHDGSSTR 1680 EDSMEISVTD GLTVTMLEVR VEVSLSEDRG PRLAAGSSLS ITVASKSTAI ITRSHLAYVD 1740 DSSPDPEIWI QLNYLPSYGT LLRTSGSEVE ELSEVSNFTM EDINNKKIRY SAVFETDGHL 1800 VTDSFYFSVS DMDHNHLDNQ IFTIMITPAE NPPPVIAFAD LITVDEGGRA PLSFHHFFAT 1860 DDDDNLQRDA IIKLSALPKY GCIENTGTGD RFGPETASDL EASFPIQDVL ENYIYYFQSV 1920 HESIEPTHDI FSFYVSDGTS RSEIHSINIT IERKNDEPPR MTLQPLRVQL SSGVVISNSS 1980 LSLQDLDTPD NELIFVLTKK PDHGHVLWRQ TASEPLENGR VLVQGSTFTY QDILAGLVGY 2040 VPSVPGMVVD EFQFSLTDGL HVDTGRMKIY TELPASDTPH LAINQGLQLS AGSVARITEQ 2100 HLKVTDIDSD DHQVMYIMKE DPGAGHLQMM KHGNLEQISI KGPIRSFTQA DISQGHVEYS 2160 HGTGEPGGSF AFKFDVVDGE GNRLIDKSFS ISVLEDKSPP VIITNKGLVL DENSVKKITT 2220 LQLSATDQDS GPTELIYRIT RQPQLGHLEH ATSPGIQISS FTQADLTSRN VQYVHSSEAE 2280 KHSDAFSFTL SDGVNEVTQT FHITLHPVDD SLPVIQNLGM QVQEGMRKTI TEFELKAVDA 2340 DTEAESVTFT IVQPPRHGTI ERTSNGQHFH LTSTFTMEDI YQNRVSYSHD GSNSLKDRFT 2400 FTVSDGTNPF FIIEEGGKEI MTAAPQPFRV DILPVDDGTP RIVTNLGLQW LEYMDGKATN 2460 LITKKELLTM DPDTEDAQLV YEITTGPKHG FVENKLQPGR AAATFTQEDV NLGLIRYVLH 2520 KEKIREMMDS FQFLVKDSKP NVVSDNVFHI QWSLISFKYT SYNVSEKAGS VSVTVQRTGN 2580 LNQYAIVLCR TEQGTASSSS RVSSQPGQQD YVEYAGQVQF DEREDTKSCT IVINDDDVFE 2640 NVESFTVELS MPAYALLGEF TQAKVIINDT EDEPTLEFDK KIYRVNESAG FLFAPIERKG 2700 DASSIVSAIC YTVPKSAMGS SLYALESGSD FKSRGMSAAS RVIFRPGVTM STCDVMLIDD 2760 SEYEEEEEFE IALADASDNA RIGRVATAKV LISGPNDAST VSLGNTAFTV SEDAGTVKIP 2820 VIRHGTDLST FTSVWCATRP SDPASATPGV DYVPSSRKVE FGPGVIEQYC TLTILDDTQY 2880 PVIEGLETFV VFLSSAQGAE LTKPFQAVIA INDTFQDVPS MQFAKDLLLV KEKEGVLHVP 2940 ITRSGDLSYE SSVRCYTQSH SAQVMEDFEE RQNADSSRIT FLKGDKVKNC TVYIHDDSMF 3000 EPEEQFRVYL GLPLGNHWSG ARIGKNNMAT ITISNDEDAP TIEFEEAAYQ VREPAGPDAI 3060 AILNIKVIRR GDQNRTSKVR CSTRDGSAQS GVDYYPKSRV LKFSPGVDHI FFKVEILSNE 3120 DREWHESFSL VLGPDDPVEA VLGDVTTATV TILDQEAAGS LILPAPPIVV TLADYDHVEE 3180 VTKEGVKKSP SPGYPLVCVT PCDPHFPRYA VMKERCSEAG INQTSVQFSW EVAAPTDGNG 3240 ARSPFETITD NTPFTSVNHM VLDSIYFSRR FHVRCVAKAV DKVGHVGTPL RSNIVTIGTD 3300 SAICHTPVVA GTSRGFQAQS FIATLKYLDV KHKEHPNRIH ISVQIPHQDG MLPLISTMPL 3360 HNLHFLLSES IYRHQHVCSN LVTTYDLRGI SEAGFLDDVV YDSTALGPGY DRPFQFDPSV 3420 REPKTIQLYK HLNLKSCVWT FDAYYDMTEL IDVCGGSVTA DFQVRDSAQS FLTVHVPLYV 3480 SYIYVTAPRG WASLEHHTEM EFSFFYDTVL WRTGIQTDSV LSARLQIIRI YIREDGRLVI 3540 EFKTHAKFRG QFVMEHHTLP DVKSFILTPD HLGGIEFDLQ LLWSAQTFDS PHQLWRATSS 3600 YNRKDYSGEY TIYLIPCTVQ PTQPWVDPGE KPLACTAHAP ERFLIPIAFQ QTNRPVPVVY 3660 SLNTEFQLCN NEKVFLMDPN TSDMSLAEMD YKGAFSKGQI LYGRVLWNPE QNLNSAYKLQ 3720 LEKVYLCTGK DGYVPFFDPT GTIYNEGPQY GCIQPNKHLK HRFLLLDRNQ PEVTDKYFHD 3780 VPFEAHFASE LPDFHVVSNM PGVDGFTLKV DALYKVEAGH QWYLQVIYII GPDTISGPRV 3840 QRSLTAPLRR NRRDLVEPNG QLILDDSLIY DNEGDQVKNG TNMKSLNLEM QELAVAASLS 3900 QTGASIGSAL AAIMLLLLVF LVACFINRKC QKQRKKKPAE DILEEYPLNT KVEVPKRHPD 3960 RVEKNVNRQY CTVRNVNILS EPEAAYTFKG AKVKRLNLEV RVHNNLQDGT EV 4012 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FRAS1 | 478446 | J9P6T8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FRAS1 | A0A452G0M2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FRAS1 | 80144 | Q86XX4 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fras1 | 231470 | Q80T14 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | FRAS1 | 461226 | H2R4C8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Fras1 | F1M3H3 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | fras1 | 563428 | F1Q633 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005604 | basement membrane |
| GO:0016021 | integral component of membrane |
| GO:0007154 | cell communication |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0003338 | metanephros morphogenesis |
| GO:0002009 | morphogenesis of an epithelium |
| GO:0015031 | protein transport |
| GO:0060021 | roof of mouth development |
| GO:0043588 | skin development |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |