Gene: BPNT2

Basic information

Tag Content
Uniprot ID F1RT67
Entrez ID 100156925
Genbank protein ID
Genbank nucleotide ID NM_001243632.1
Ensembl protein ID ENSSSCP00065021793; ENSSSCP00030027568; ENSSSCP00060036599; ENSSSCP00025013224; ENSSSCP00035023038; ENSSSCP00040012361; ENSSSCP00045023650; ENSSSCP00055039839; ENSSSCP00015032630; ENSSSCP00050031002; ENSSSCP00070004996; ENSSSCP00000041117;
Ensembl nucleotide ID ENSSSCG00035043150; ENSSSCG00055025239; ENSSSCG00060061949; ENSSSCG00045019989; ENSSSCG00000032846; ENSSSCG00030043195; ENSSSCG00050052949; ENSSSCG00025023245; ENSSSCG00070003183; ENSSSCG00015060402; ENSSSCG00065036885; ENSSSCG00040022038;
Gene name Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase
Gene symbol BPNT2
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.
Sequence
MAPMGIRLSP LGVAVFCLLG LGVLYHLYSG FLAGRFSLFG MGGEPGGGAA GPGAAADGGT 60
VDLREMLAVS VLAAVRGGDE VRRVRESNVL HEKSKGKTRE GADDKMTSGD VLSNRKMFYL 120
LKTAFPNVQI NTEEHVDATD QEVILWDRKI PEDILKEIAT PQEVPAESVT VWIDPLDATQ 180
EYTEDLRKYV TTMVCVAVNG KPVLGVIHKP FSEYTAWAMV DGGSNVKART SYNEKTPRIV 240
VSRSHSGMVK QVALQTFGNQ TTIIPAGGAG YKVLALLDVP DKSQEKADLY IHVTYIKKWD 300
ICAGNAILKA LGGHMTTLSG EEISYTGSDG IEGGLLASVR VDHQALVRKL PDLEKTGHK 359

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBPNT2532797Q2KJ53Bos taurusPredictionMore>>
1:1 orthologBPNT2477890E2RMJ7Canis lupus familiarisPredictionMore>>
1:1 orthologIMPAD1A0A452ECA6Capra hircusPredictionMore>>
1:1 orthologBPNT254928Q9NX62Homo sapiensPredictionMore>>
1:1 orthologBpnt2242291Q80V26CPOMus musculusPublicationMore>>
1:1 orthologBPNT2100156925F1RT67Sus scrofaPredictionMore>>
1:1 orthologIMPAD1100343037G1SLS8Oryctolagus cuniculusPredictionMore>>
1:1 orthologbpnt2641570Q2YDR3Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005829 cytosol
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0016604 nuclear body
GO:0032588 trans-Golgi network membrane
GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity
GO:0097657 3',5'-nucleotide bisphosphate phosphatase activity
GO:0008254 3'-nucleotidase activity
GO:0046872 metal ion binding
GO:0002063 chondrocyte development
GO:0030204 chondroitin sulfate metabolic process
GO:0042733 embryonic digit morphogenesis
GO:0001958 endochondral ossification
GO:0046855 inositol phosphate dephosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0009791 post-embryonic development
GO:0001501 skeletal system development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0325 Glycoprotein
KW-0333 Golgi apparatus
KW-0378 Hydrolase
KW-0460 Magnesium
KW-0472 Membrane
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0735 Signal-anchor
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS

PROSITE

PROSITE ID PROSITE Term
PS00630 IMP_2

Pfam

Pfam ID Pfam Term
PF00459 Inositol_P