Gene: Bpnt2

Basic information

Tag Content
Uniprot ID Q80V26; A6H6P6;
Entrez ID 242291
Genbank protein ID AAI45953.1; EDL05698.1; AAH48776.1; AAI38210.1;
Genbank nucleotide ID NM_177730.3
Ensembl protein ID ENSMUSP00000082013
Ensembl nucleotide ID ENSMUSG00000066324
Gene name Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase
Gene symbol Bpnt2
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 18539921
Functional description Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate (PubMed:18695242). May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (PubMed:18695242). Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.
Sequence
MAPMGIRLSP LGVAVFFLLG LGVLYHLYSG FLAGRFSLFG LGSEPAAGEA EVASDGGTVD 60
LREMLAVAVL AAERGGDEVR RVRESNVLHE KSKGKTREGA DDKMTSGDVL SNRKMFYLLK 120
TAFPNVQINT EEHVDASDKE VIVWNRKIPE DILKEIAAPK EVPAESVTVW IDPLDATQEY 180
TEDLRKYVTT MVCVAVNGKP VLGVIHKPFS EYTAWAMVDG GSNVKARSSY NEKTPKIIVS 240
RSHAGMVKQV ALQTFGNQTS IIPAGGAGYK VLALLDVPDM TQEKADLYIH VTYIKKWDIC 300
AGNAILKALG GHMTTLNGEE ISYTGSDGIE GGLLASIRMN HQALVRKLPD LEKSGH 356

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBPNT2532797Q2KJ53Bos taurusPredictionMore>>
1:1 orthologBPNT2477890E2RMJ7Canis lupus familiarisPredictionMore>>
1:1 orthologIMPAD1A0A452ECA6Capra hircusPredictionMore>>
1:1 orthologBPNT254928Q9NX62Homo sapiensPredictionMore>>
1:1 orthologBpnt2242291Q80V26CPOMus musculusPublicationMore>>
1:1 orthologBPNT2100156925F1RT67Sus scrofaPredictionMore>>
1:1 orthologIMPAD1100343037G1SLS8Oryctolagus cuniculusPredictionMore>>
1:1 orthologbpnt2641570Q2YDR3Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0008254 3'-nucleotidase activityIDA
GO:0008254 3'-nucleotidase activityIBA
GO:0008441 3'(2'),5'-bisphosphate nucleotidase activityIEA
GO:0046872 metal ion bindingIEA
GO:0097657 3',5'-nucleotide bisphosphate phosphatase activityIDA

GO:Biological Process

GO ID GO Term Evidence
GO:0001501 skeletal system developmentIMP
GO:0001501 skeletal system developmentIBA
GO:0001958 endochondral ossificationIMP
GO:0002063 chondrocyte developmentIMP
GO:0009791 post-embryonic developmentIMP
GO:0016311 dephosphorylationIEA
GO:0030204 chondroitin sulfate metabolic processIMP
GO:0042733 embryonic digit morphogenesisIMP
GO:0046854 phosphatidylinositol phosphorylationIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005654 nucleoplasmISO
GO:0005794 Golgi apparatusISO
GO:0005829 cytosolISO
GO:0012505 endomembrane systemIBA
GO:0016021 integral component of membraneIEA
GO:0016604 nuclear bodyISO
GO:0032588 trans-Golgi network membraneIDA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1430728 MetabolismIEA
R-MMU-156580 Phase II - Conjugation of compoundsIEA
R-MMU-156584 Cytosolic sulfonation of small moleculesIEA
R-MMU-211859 Biological oxidationsIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0325 Glycoprotein
KW-0333 Golgi apparatus
KW-0378 Hydrolase
KW-0460 Magnesium
KW-0472 Membrane
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0735 Signal-anchor
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS

PROSITE

PROSITE ID PROSITE Term
PS00630 IMP_2

Pfam

Pfam ID Pfam Term
PF00459 Inositol_P