| Tag | Content |
|---|---|
| Uniprot ID | Q2KJ53 |
| Entrez ID | 532797 |
| Genbank protein ID | AAI05515.1 |
| Genbank nucleotide ID | NM_001046335.1 |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase |
| Gene symbol | BPNT2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4. |
| Sequence | MAPMGIRLSP LGVAVFCLLG LGVLYHLYSG FLAGRFSLFG LGGEPGGGAA GPAGPAASAD 60 GGTVDLREML AVSVLAAVRG GEEVRRVRES NVLHEKSKGK TREGADDKMT SGDVLSNRKM 120 FYLLKTAFPS VQINTEEHVD ASDQEVILWD RKIPEDILKE IATPQEVPAE SVTVWIDPLD 180 ATQEYTEDLR KYVTTMVCVA VNGKPVLGVI HKPFSEYTAW AMVDGGSNVK ARTSYNEKTP 240 RIVVSRSHSG MVKQVALQTF GNQTTIIPAG GAGYKVLALL DVPDKSQEKA DLYIHVTYIK 300 KWDICAGNAI LKALGGHMTT LSGEEISYTG SDGIEGGLLA SIRMNHQALV RKLPDLEKTG 360 HK 362 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BPNT2 | 532797 | Q2KJ53 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BPNT2 | 477890 | E2RMJ7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | IMPAD1 | A0A452ECA6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | BPNT2 | 54928 | Q9NX62 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bpnt2 | 242291 | Q80V26 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | BPNT2 | 100156925 | F1RT67 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | IMPAD1 | 100343037 | G1SLS8 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | bpnt2 | 641570 | Q2YDR3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0012505 | endomembrane system |
| GO:0016021 | integral component of membrane |
| GO:0032588 | trans-Golgi network membrane |
| GO:0008441 | 3'(2'),5'-bisphosphate nucleotidase activity |
| GO:0097657 | 3',5'-nucleotide bisphosphate phosphatase activity |
| GO:0008254 | 3'-nucleotidase activity |
| GO:0046872 | metal ion binding |
| GO:0046855 | inositol phosphate dephosphorylation |
| GO:0046854 | phosphatidylinositol phosphorylation |
| GO:0001501 | skeletal system development |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00630 | IMP_2 |
| Pfam ID | Pfam Term |
|---|---|
| PF00459 | Inositol_P |