| Tag | Content |
|---|---|
| Uniprot ID | F1STS1 |
| Entrez ID | 100525584 |
| Genbank protein ID | HDB70768.1 |
| Genbank nucleotide ID | XM_005656059.2; XM_003127716.5; XM_003356221.3; XM_005656073.2; |
| Ensembl protein ID | ENSSSCP00000003863 |
| Ensembl nucleotide ID | ENSSSCG00000040007 |
| Gene name | GPI mannosyltransferase 2 |
| Gene symbol | PIGV |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. |
| Sequence | MWPLDPSLKE VLGFAVGCRV LTLVLQAFFN AIIPDHRAEA FSPPRFGPSS SVDQLVEGLL 60 GGLSHWDAEH FLFIAEHGYL YEHNFAFFPG FPLVLLVGTE LLRPLWGLLS LRSCLLISVA 120 LLNSLFSVLA ALALHDLGCL VLHCPRQAFY GALLFCLSPA NVFLTAGYSE ALFALLTFSA 180 MAQLERGRSW TSGLLFALAT GVRANGLVNV GFLVHSQCQG FFSSLTMRNP LRQLLKLMGS 240 VFLSVLSLGL PFGLFQYYAY TQFCVQGSAH PIPKPLLQLA LDKGYRVAEG NEPPWCSWKL 300 PLVYSYVQDI YWNVGFLRYY ELKQVPNFLL AAPMAVLVAW ATWTYVTTHP WLCLTLGMQR 360 NKNNKSLEKP DPGFLSPRVF VYLVHAAVLL LFGSLCMHVQ VLTRFLCSST PIVYWFSAHL 420 LHDREPPLRS LKTVPWKPLA EDFPPGQKVP RNSIMGLLYN WKACSLVTRC ILGYFLTYWL 480 LGLLLHCNFL PWT 493 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PIGV | 519213 | E1B9Z8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PIGV | 102189531 | A0A452FYH8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PIGV | 55650 | Q9NUD9 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pigv | 230801 | Q7TPN3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PIGV | 101059423 | K7DNW1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PIGV | 100525584 | F1STS1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Pigv | 366478 | Q5KR61 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pigv | 100148642 | A0A0R4ITR4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0016021 | integral component of membrane |
| GO:0031501 | mannosyltransferase complex |
| GO:0004584 | dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity |
| GO:0000030 | mannosyltransferase activity |
| GO:0006506 | GPI anchor biosynthetic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR007315 | PIG-V/Gpi18 |
| Pfam ID | Pfam Term |
|---|---|
| PF04188 | Mannosyl_trans2 |