Gene: PIGV

Basic information

Tag Content
Uniprot ID K7DNW1; A0A2J8JNV4;
Entrez ID 101059423
Genbank protein ID JAA27953.1; JAA37432.1;
Genbank nucleotide ID XM_016956960.1; XM_016956965.1; XM_016956976.1; XM_016956969.1; XM_016956968.1; XM_016956978.1; XM_016956972.1; XM_016956963.1;
Ensembl protein ID ENSPTRP00000074722
Ensembl nucleotide ID ENSPTRG00000047988
Gene name GPI mannosyltransferase 2
Gene symbol PIGV
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Sequence
MWPQDPSRKE VLRFAVSCRI LTLMLQALFN AIIPDHHAEA FSPPRLAPSG FVDQLVEGLL 60
GGLSHWDAEH FLFIAEHGYL YEHNFAFFPG FPLALLVGTE LLRPLRGLLS LRSCLLISVA 120
SLNFLFFMLA AVALHDLGCL VLHCPRQSFY AALLFCLSPA NVFLAAGYSE ALFALLTFSA 180
MGQLERGRVW TSVLLFAIAT GVRSNGLVSV GFLMHSQCQG FFSSLTMLNP LRQLFKLMAS 240
LFLSVFTLGL PFALFQYYAY TQFCLPGSAR PIPEPLVQLA VDKGYRIAEG NEPPWCFWDV 300
PLIYSYIQDV YWNVGFLKYY ELKQVPNFLL AAPVAILVAW ATWTYVTTHP WLCLTLGLQR 360
SKNNKTLEKP NLGFLSPQVF VYVVHAAVLL LFGGLCMHVQ VLTRFLGSST PIMYWFPAHL 420
LQDQEPLLRS LKTVPWKPLA EDSPPGQKVP RNPIMGLLYH WKTCSPVTRY ILGYFLTYWL 480
LGLLLHCNFL PWT 493

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPIGV519213E1B9Z8Bos taurusPredictionMore>>
1:1 orthologPIGV102189531A0A452FYH8Capra hircusPredictionMore>>
1:1 orthologPIGV55650Q9NUD9Homo sapiensPredictionMore>>
1:1 orthologPigv230801Q7TPN3CPOMus musculusPublicationMore>>
1:1 orthologPIGV101059423K7DNW1Pan troglodytesPredictionMore>>
1:1 orthologPIGV100525584F1STS1Sus scrofaPredictionMore>>
1:1 orthologPigv366478Q5KR61Rattus norvegicusPredictionMore>>
1:1 orthologpigv100148642A0A0R4ITR4Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031501 mannosyltransferase complex
GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
GO:0000030 mannosyltransferase activity
GO:0006506 GPI anchor biosynthetic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0256 Endoplasmic reticulum
KW-0328 Glycosyltransferase
KW-0337 GPI-anchor biosynthesis
KW-0472 Membrane
KW-1185 Reference proteome
KW-0808 Transferase
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR007315 PIG-V/Gpi18

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF04188 Mannosyl_trans2