Gene: Pigv

Basic information

Tag Content
Uniprot ID Q7TPN3; Q8BGL2; Q8BJR5; Q8BWH9; Q8BXF5;
Entrez ID 230801
Genbank protein ID BAC38047.1; BAC37950.1; AAH55060.1; BAC34995.1; BAC32773.1; BAC33023.1; BAE28458.1;
Genbank nucleotide ID NM_001145955.1; NM_001145956.1; XM_006538747.3; NM_178698.5;
Ensembl protein ID ENSMUSP00000050647; ENSMUSP00000065601;
Ensembl nucleotide ID ENSMUSG00000043257
Gene name GPI mannosyltransferase 2
Gene symbol Pigv
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 25807483
Functional description Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
Sequence
MGLLDPSQKE VLRFAVNCRI LTLVLQALFN LIIPDHHADA FCPPRLAPSG SADQLVEGLL 60
GGLSRWDAEH FLFIAEHGYL YEHNFAFFPG FPLALLMGTE LLRPLQGLLS QRSCLLVSVA 120
LLNLLFSVLA AVALHDLGCL VLHCPRQALC AALLFCISPA NVFLAAGYSE ALFAFLTFSA 180
MGQLERGRGW ASGLLFALAA GVRSNGLVSL GFLLHSQCRG FCSSLAVLSP WKPLVKLMAS 240
VCLSVLIVSL PFALFQYRAY IQFCSPGSAP SIPEPLLQLA ADKGYRLAGE NAPPWCSWDL 300
PLIYNYIQDV YWNVGLLRYY ELKQVPNFLL ATPVTVLVVW ATWTYVTTHP WLCLTLGLQR 360
TKDRENPEKP HRGFLSPKVF VYLVHAAALL VFGGLCMHVQ VLTRFLASST PIMYWFPAHL 420
LQDQEPLLRC VDTEPGKLPQ EKSPPGQKAP RNCLMKLFYD WKRCSPVTRC VLVYFLTYWL 480
LGLILHCNFL PWT 493

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPIGV519213E1B9Z8Bos taurusPredictionMore>>
1:1 orthologPIGV102189531A0A452FYH8Capra hircusPredictionMore>>
1:1 orthologPIGV55650Q9NUD9Homo sapiensPredictionMore>>
1:1 orthologPigv230801Q7TPN3CPOMus musculusPublicationMore>>
1:1 orthologPIGV101059423K7DNW1Pan troglodytesPredictionMore>>
1:1 orthologPIGV100525584F1STS1Sus scrofaPredictionMore>>
1:1 orthologPigv366478Q5KR61Rattus norvegicusPredictionMore>>
1:1 orthologpigv100148642A0A0R4ITR4Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000030 mannosyltransferase activityISO
GO:0000030 mannosyltransferase activityIBA
GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activityIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0006506 GPI anchor biosynthetic processIEA
GO:0006506 GPI anchor biosynthetic processISO
GO:0006506 GPI anchor biosynthetic processIBA
GO:0097502 mannosylationIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005789 endoplasmic reticulum membraneISO
GO:0005789 endoplasmic reticulum membraneIBA
GO:0016021 integral component of membraneIEA
GO:0031501 mannosyltransferase complexIBA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI)IEA
R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteinsIEA
R-MMU-392499 Metabolism of proteinsIEA
R-MMU-597592 Post-translational protein modificationIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0256 Endoplasmic reticulum
KW-0328 Glycosyltransferase
KW-0337 GPI-anchor biosynthesis
KW-0472 Membrane
KW-1185 Reference proteome
KW-0808 Transferase
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR007315 PIG-V/Gpi18

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF04188 Mannosyl_trans2

Protein-miRNA interaction