| Tag | Content |
|---|---|
| Uniprot ID | Q5KR61 |
| Entrez ID | 366478 |
| Genbank protein ID | BAD88519.1 |
| Genbank nucleotide ID | XM_017593545.1; XM_006239055.3; NM_001010966.1; XM_017593544.1; XM_017593542.1; XM_017593543.1; XM_008764159.2; |
| Ensembl protein ID | ENSRNOP00000000133; ENSRNOP00000073811; |
| Ensembl nucleotide ID | ENSRNOG00000000121 |
| Gene name | GPI mannosyltransferase 2 |
| Gene symbol | Pigv |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity). |
| Sequence | MGLLDPSQKE VLKFAVSCRI LTLVLQALFN IIIPDHHADA FSPPRLAPSG SVDQLVEALL 60 GGLSRWDAEH FLFIAEHGYL YEHNFAFFPG FPLALLMGTE LLRPLQGLLS ERSCLLVSVA 120 LLNSLFSVLA AVALHDLGCL VLHCPRQAFC AALLFCLSPA NVFLAAGYSE ALFAFLTFSA 180 MGQLERGRGW ASGLLFALAA GVRSNGLVSV GFLLHSQCRG FCSSLVVLDP LKGLVKLMAS 240 LCLSVLTVSL PFALFQYYAY TQFCFPGSAH AIPEPLLRLA SDRGYRLAGD YEPPWCSRAP 300 PLIYSYIQDV YWNVGLLRYY ELRQVPNFLL ATPVTVLVVW ATWTYVTAHP WLCLTLGLQR 360 TKDRESLEKP HPGFLSAKVF VYLVHAAALL AFGGLCMHVQ VLTRLLGSST PITYWFPAYL 420 LQDREPLLRC VDTAPQKLLE NSPPGQKAPR NCVMKLLYNW KTCSPVTKCI LVYFLTYWLL 480 GLIMHCNFLP WT 492 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PIGV | 519213 | E1B9Z8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PIGV | 102189531 | A0A452FYH8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PIGV | 55650 | Q9NUD9 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pigv | 230801 | Q7TPN3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PIGV | 101059423 | K7DNW1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PIGV | 100525584 | F1STS1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Pigv | 366478 | Q5KR61 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pigv | 100148642 | A0A0R4ITR4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0016021 | integral component of membrane |
| GO:0031501 | mannosyltransferase complex |
| GO:0004584 | dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity |
| GO:0000030 | mannosyltransferase activity |
| GO:0006506 | GPI anchor biosynthetic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR007315 | PIG-V/Gpi18 |
| Pfam ID | Pfam Term |
|---|---|
| PF04188 | Mannosyl_trans2 |