| Tag | Content |
|---|---|
| Uniprot ID | F6Z985 |
| Entrez ID | 100050052 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_001488203.5 |
| Ensembl protein ID | ENSECAP00000016539 |
| Ensembl nucleotide ID | ENSECAG00000018874 |
| Gene name | Prickle planar cell polarity protein 1 |
| Gene symbol | PRICKLE1 |
| Organism | Equus caballus |
| NCBI taxa ID | 9796 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPLEMEPKMS KLAFGCQRSS TSDDDSGCAL EEYAWVPPGL RPEQIQLYFA CLPEEKVPYV 60 NSPGEKHRIK QLLYQLPPHD NEVRYCQSLS EEEKKELQVF SAQRKKEALG RGTIKLLSRA 120 VMHAVCEQCG LKINGGEIAV FASRAGPGIC WHPSCFVCFT CNELLVDLIY FYQDGKIHCG 180 RHHAELLKPR CSACDEIIFA DECTEAEGRH WHMKHFCCLE CETVLGGQRY IMKDGRPFCC 240 GCFESLYAEY CETCGEHIGV DHAQMTYDGQ HWHATEACFS CAQCKASLLG CPFLPKQGQI 300 YCSKTCSLGE DVHASDSSDS AFQSARSRDS RRSVRMGKSS RSADQCRQSL LLSPALNYKF 360 PGLSGNADDT LSRKLDDLSL SRQGASFVNE EFWKGRVEHE TPEDPEEWAE HEDYMTQLLL 420 KFGDKSLFQQ QPNEMDIRAS EHWISDNMVK NKTELKQNNQ SLASKKYQSD MYWAQSQDGL 480 GDSAYGSHPG PASSRRLQEL DLDHGAAGYN HDQTQWYEDS LECLSDLKPE HSVRDSMDSL 540 ALSNITGASV DGESKPRPSL YSLQNFEEME AEDCEKMSNM GTLNSSMLHR SAESLKSLSS 600 ELCPEKIMPE EKPVHLPVLR RSKSQSRPQQ VKFSDDVIDN GNYDNIEIRQ PPMSERTRRR 660 VYHFEERGSR SHHHRRRRSR KSRSDNALNL VTERKYSPKD RLRLYTPDSY EKFIQNKSAR 720 EIQAYIQNAD LYGQYAHATS DYALQNPGVH RFLGLYGEDD DSWCSSSTSS SDSEEEGYFL 780 GQPIPQPRPQ RYAYYTDDLS SPTSALPTPQ FGQRTTKSKK KKGHKGKNCI IS 832 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PRICKLE1 | 102182103 | A0A452ECU1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PRICKLE1 | 100050052 | F6Z985 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | PRICKLE1 | 144165 | Q96MT3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Prickle1 | 106042 | Q3U5C7 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PRICKLE1 | 451838 | A0A2I3TH70 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PRICKLE1 | G1TZ88 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Prickle1 | 315259 | G3V8Z4 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | prickle1a | 368249 | F1Q6J9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0031965 | nuclear membrane |
| GO:0008270 | zinc ion binding |
| GO:0035904 | aorta development |
| GO:0060976 | coronary vasculature development |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:2000691 | negative regulation of cardiac muscle cell myoblast differentiation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0001843 | neural tube closure |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:0031398 | positive regulation of protein ubiquitination |
| GO:0006606 | protein import into nucleus |