| Tag | Content |
|---|---|
| Uniprot ID | G3V8Z4 |
| Entrez ID | 315259 |
| Genbank protein ID | EDL76630.1; EDL76631.1; EDL76629.1; |
| Genbank nucleotide ID | NM_199396.1; XM_006242215.3; XM_017594887.1; XM_006242213.3; XM_006242214.3; |
| Ensembl protein ID | ENSRNOP00000031476 |
| Ensembl nucleotide ID | ENSRNOG00000022772 |
| Gene name | Prickle-like 1 (Drosophila), isoform CRA_a |
| Gene symbol | Prickle1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPLEMEPKMS KLAFGCQRSS TSDDDSGCAL EEYAWVPPGL RPEQIQLYFA CLPEEKVPYV 60 NSPGEKHRIK QLLYQLPPHD NEVRYCQSLS EEEKKELQVF SAQRKKEALG RGTIKLLSRA 120 MMHAVCEQCG LQMNGGEVAV FASRAGPGVC WHPSCFVCFT CNELLVDLIY FYQDGKIHCG 180 RHHAELLKPR CSACDEIIFA DECTEAEGRH WHMKHFCCLE CETVLGGQRY IMKDGRPFCC 240 GCFESLYAEY CETCGEHIGV DHAQMTYDGQ HWHATEACFS CAQCKASLLG CPFLPKQGQI 300 YCSKTCSLGE DIHASDSSDS AFQSARSRDS RRSVRMGRSS RSADQCRQSL LLSPALNYKF 360 PGLSGSADDT LSRKLDDVSL SGQGAGFAHE EFWKARVDQE ASEDPEEWAE HEDYMTQLLL 420 KFGDKNLFQQ PPSEVDMRAS EHWIPDNMVT NKPEAKQNHQ SLASKKYQSD MYWAQSQDGL 480 GDSAYGSHPG PASSRRLQEL DLDHGAAGYN HDQTQWYEDS LECLSDLKPE QSVRDSMDSL 540 ALSNITGASV DGESKPRPSL YSLQNFEEIE AEDCEKMSNM GTLNSSMLHR SAESLKSLNS 600 ELCPEKIIPE EKPVHLPVLR RSKSQSRPQQ VKFSDDVIDN GSYDIEIRQP PMSERTRRRV 660 YHFEERGSRP HHHRHRRSRK SRSDNALNLV TERKYSAKDR LRLYTPDNYE KFIQSKGARE 720 LQAYMQNANL YGQYAHTTSD YALQNPGMTR FLGLYGDDDD SWCSSSTSSS DSEEEGYFLG 780 QPIPQPRPQR FTYYTDDLSS PASALPTPQF NQRTTKSKKK KGHRGKNCII S 831 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PRICKLE1 | 102182103 | A0A452ECU1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PRICKLE1 | 100050052 | F6Z985 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | PRICKLE1 | 144165 | Q96MT3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Prickle1 | 106042 | Q3U5C7 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PRICKLE1 | 451838 | A0A2I3TH70 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PRICKLE1 | G1TZ88 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Prickle1 | 315259 | G3V8Z4 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | prickle1a | 368249 | F1Q6J9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0031965 | nuclear membrane |
| GO:0008270 | zinc ion binding |
| GO:0035904 | aorta development |
| GO:0060976 | coronary vasculature development |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:2000691 | negative regulation of cardiac muscle cell myoblast differentiation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0001843 | neural tube closure |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:0031398 | positive regulation of protein ubiquitination |
| GO:0006606 | protein import into nucleus |