| Tag | Content |
|---|---|
| Uniprot ID | Q3U5C7 |
| Entrez ID | 106042 |
| Genbank protein ID | AAI17894.1; BAE32152.1; AAI17893.1; |
| Genbank nucleotide ID | XM_006520264.3; XM_006520266.3; XM_006520265.1; NM_001033217.4; |
| Ensembl protein ID | ENSMUSP00000104878; ENSMUSP00000049204; |
| Ensembl nucleotide ID | ENSMUSG00000036158 |
| Gene name | Prickle-like protein 1 |
| Gene symbol | Prickle1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 26883626; 25190059; 24689077; |
| Functional description | Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity). Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor (By similarity). |
| Sequence | MPLEMEPKMS KLVFGCQRSS TSDDDSGCAL EEYAWVPPGL RPEQIQLYFA CLPEEKVPYV 60 NSPGEKHRIK QLLYQLPPHD NEVRYCQSLS EEEKKELQVF SAQRKKEALG RGTIKLLSRA 120 VMHAVCEQCG LQMNGGEVAV FASRAGPGVC WHPSCFVCFT CNELLVDLIY FYQDGKIHCG 180 RHHAELLKPR CSACDEIIFA DECTEAEGRH WHMKHFCCLE CETVLGGQRY IMKDGRPFCC 240 GCFESLYAEY CETCGEHIGV DHAQMTYDGQ HWHATEACFS CAQCKASLLG CPFLPKQGQI 300 YCSKTCSLGE DIHASDSSDS AFQSARSRDS RRSVRMGRSS RSADQCRQSL LLSPALNYKF 360 PGLSGNADDT LSRKLDDVSL ASRQGAGFAN EEFWKARVEQ EASEDPEEWA EHEDYMTQLL 420 LKFGDKNLFQ QQSSEVDPRA SEHWIPDNMV TNKPEVKPNH QGLASKKYQS DMYWAQSQDG 480 LGDSAYGSHP GPASSRRLQE LDLDHGAAGY THDQSQWYED SLECLSDLKP EQSIRDSMDS 540 LALSNITGAS VDGESKPRPS LYSLQNFEEI EAEDCEKMSN MGTLNSSMLH RSAESLQSLN 600 SGLCPEKILP EEKPAHLPVL RRSKSQSRPQ QVKFSDDVID NGSYDIEIRQ PPMSERTRRR 660 AYHFEERGSR PHHHRHRRSR KSRSDNALNL VTERKYSAKD RLRLYTPDNY EKFIQNKSAR 720 ELQAYMQNAN LYSQYAHATS DYALQNPGMN RFLGLCGEDD DSWCSSSTSS SDSEEEGYFL 780 GQPIPQPRPQ RFTYYTDDLS SPASALPTPQ FTQRTTKSKK KKGHKGKNCI IS 832 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PRICKLE1 | 102182103 | A0A452ECU1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PRICKLE1 | 100050052 | F6Z985 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | PRICKLE1 | 144165 | Q96MT3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Prickle1 | 106042 | Q3U5C7 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PRICKLE1 | 451838 | A0A2I3TH70 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PRICKLE1 | G1TZ88 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Prickle1 | 315259 | G3V8Z4 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | prickle1a | 368249 | F1Q6J9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0008134 | transcription factor binding | ISO |
| GO:0008270 | zinc ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001843 | neural tube closure | ISO |
| GO:0006606 | protein import into nucleus | ISO |
| GO:0031398 | positive regulation of protein ubiquitination | ISO |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | ISO |
| GO:0035904 | aorta development | IMP |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISO |
| GO:0060976 | coronary vasculature development | IMP |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | ISO |
| GO:2000691 | negative regulation of cardiac muscle cell myoblast differentiation | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005829 | cytosol | ISO |
| GO:0031965 | nuclear membrane | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-3858494 | Beta-catenin independent WNT signaling | IEA |
| R-MMU-4086400 | PCP/CE pathway | IEA |
| R-MMU-4608870 | Asymmetric localization of PCP proteins | IEA |