Gene: CASP3

Basic information

Tag Content
Uniprot ID F7A730
Entrez ID 100034083
Genbank protein ID AEQ00049.1
Genbank nucleotide ID NM_001163961.1
Ensembl protein ID ENSECAP00000019797
Ensembl nucleotide ID ENSECAG00000022197
Gene name Caspase 3
Gene symbol CASP3
Organism Equus caballus
NCBI taxa ID 9796
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MENSKISVDS KSIKNSETKI LHGSKSMDSG ISLDSSYKMD YPEMGLCIII NNKNFHKSTG 60
MASRSGTDVD AANLRETFTN LKYEVRNKND LTGEEIVALM RSVSKEDHSK RSSFICVLLS 120
HGEEGIIFGT NGPIDLKKLT CFFKGDCCRS LAGKPKLFII QACRGTELDS GIETDSGIED 180
DMACQKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC AMLKLYAHKL ELMHILTRVN 240
RKVAMEFESY CLDPTFHGKK QIPCIVSMLT KELYFYH 277

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCASP3F1MB04Bos taurusPredictionMore>>
1:1 orthologCASP3102177031H9B8T7Capra hircusPredictionMore>>
1:1 orthologCASP3100034083F7A730Equus caballusPredictionMore>>
1:1 orthologCASP3836P42574Homo sapiensPredictionMore>>
1:1 orthologCasp312367P70677CPOMus musculusPublicationMore>>
1:1 orthologCASP3461669Q5IS54Pan troglodytesPredictionMore>>
1:1 orthologCasp325402P55213Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005634 nucleus
GO:0004190 aspartic-type endopeptidase activity
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0061713 anterior neural tube closure
GO:0006915 apoptotic process
GO:0001782 B cell homeostasis
GO:0045165 cell fate commitment
GO:0006974 cellular response to DNA damage stimulus
GO:0072734 cellular response to staurosporine
GO:0030218 erythrocyte differentiation
GO:0034349 glial cell apoptotic process
GO:0007507 heart development
GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress
GO:0030216 keratinocyte differentiation
GO:0046007 negative regulation of activated T cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0030889 negative regulation of B cell proliferation
GO:0051402 neuron apoptotic process
GO:0030182 neuron differentiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:1902004 positive regulation of amyloid-beta formation
GO:0043065 positive regulation of apoptotic process
GO:0016485 protein processing
GO:0031647 regulation of protein stability
GO:0009411 response to UV
GO:0009611 response to wounding
GO:0007605 sensory perception of sound
GO:0043029 T cell homeostasis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0378 Hydrolase
KW-0645 Protease
KW-1185 Reference proteome
KW-0788 Thiol protease

Interpro

InterPro ID InterPro Term
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR002398 Pept_C14
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A

PROSITE

PROSITE ID PROSITE Term
PS01122 CASPASE_CYS
PS01121 CASPASE_HIS
PS50207 CASPASE_P10
PS50208 CASPASE_P20

Pfam

Pfam ID Pfam Term