| Tag | Content |
|---|---|
| Uniprot ID | Q5IS54 |
| Entrez ID | 461669 |
| Genbank protein ID | AAV74312.1 |
| Genbank nucleotide ID | XM_016951003.1; NM_001012433.1; XM_009448539.2; XM_016951004.1; XM_009448537.2; XM_016951002.1; |
| Ensembl protein ID | ENSPTRP00000054330 |
| Ensembl nucleotide ID | ENSPTRG00000016640 |
| Gene name | Caspase-3 |
| Gene symbol | CASP3 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). |
| Sequence | MENTENSVDS KSIKNLEPKI IHGSQSMDSG ISLDNSYKMD YPEMGLCIII NNKNFHKSTG 60 MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM RDVSKEDHSK RSSFVCVLLS 120 HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS LTGKPKLFII QACRGTELDC GIETDSGVDD 180 DMACHKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC AMLKQYADKL EFMHILTRVN 240 RKVATEFESF SFDATFHAKK QIPCIVSMLT KELYFYH 277 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.