| Tag | Content |
|---|---|
| Uniprot ID | P70677; O08668; Q8CHV5; Q9QWI4; |
| Entrez ID | 12367 |
| Genbank protein ID | AAC53196.1; AAH38825.2; CAA73528.1; AAD09504.1; BAA21727.1; AAC52764.1; AAC52768.1; |
| Genbank nucleotide ID | XM_017312543.1; NM_009810.3; NM_001284409.1; |
| Ensembl protein ID | ENSMUSP00000147767; ENSMUSP00000091238; |
| Ensembl nucleotide ID | ENSMUSG00000031628 |
| Gene name | Caspase-3 |
| Gene symbol | Casp3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21515572 |
| Functional description | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. |
| Sequence | MENNKTSVDS KSINNFEVKT IHGSKSVDSG IYLDSSYKMD YPEMGICIII NNKNFHKSTG 60 MSSRSGTDVD AANLRETFMG LKYQVRNKND LTREDILELM DSVSKEDHSK RSSFVCVILS 120 HGDEGVIYGT NGPVELKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETDSGTDE 180 EMACQKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC SMLKLYAHKL EFMHILTRVN 240 RKVATEFESF SLDSTFHAKK QIPCIVSMLT KELYFYH 277 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CASP3 | F1MB04 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | CASP3 | 102177031 | H9B8T7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CASP3 | 100034083 | F7A730 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | CASP3 | 836 | P42574 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Casp3 | 12367 | P70677 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CASP3 | 461669 | Q5IS54 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Casp3 | 25402 | P55213 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002020 | protease binding | ISO |
| GO:0004190 | aspartic-type endopeptidase activity | IDA |
| GO:0004197 | cysteine-type endopeptidase activity | ISO |
| GO:0004197 | cysteine-type endopeptidase activity | IDA |
| GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity | IMP |
| GO:0005123 | death receptor binding | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0008233 | peptidase activity | ISO |
| GO:0008233 | peptidase activity | IMP |
| GO:0008233 | peptidase activity | IDA |
| GO:0008233 | peptidase activity | RCA |
| GO:0008234 | cysteine-type peptidase activity | ISO |
| GO:0008234 | cysteine-type peptidase activity | IDA |
| GO:0016005 | phospholipase A2 activator activity | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process | ISO |
| GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process | IDA |
| GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process | IBA |
| GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | ISS |
| GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | ISO |
| GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis | ISO |
| GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001554 | luteolysis | IEA |
| GO:0001666 | response to hypoxia | IEA |
| GO:0001782 | B cell homeostasis | IMP |
| GO:0006508 | proteolysis | ISO |
| GO:0006508 | proteolysis | RCA |
| GO:0006915 | apoptotic process | ISO |
| GO:0006915 | apoptotic process | IDA |
| GO:0006915 | apoptotic process | IMP |
| GO:0006915 | apoptotic process | IBA |
| GO:0006974 | cellular response to DNA damage stimulus | IDA |
| GO:0007413 | axonal fasciculation | ISO |
| GO:0007507 | heart development | IGI |
| GO:0007605 | sensory perception of sound | IMP |
| GO:0007611 | learning or memory | ISO |
| GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress | IDA |
| GO:0009411 | response to UV | IDA |
| GO:0009411 | response to UV | IGI |
| GO:0009611 | response to wounding | IDA |
| GO:0009749 | response to glucose | ISO |
| GO:0010033 | response to organic substance | IDA |
| GO:0010165 | response to X-ray | IEA |
| GO:0016485 | protein processing | IDA |
| GO:0021766 | hippocampus development | IEA |
| GO:0030182 | neuron differentiation | IBA |
| GO:0030216 | keratinocyte differentiation | IMP |
| GO:0030216 | keratinocyte differentiation | IBA |
| GO:0030218 | erythrocyte differentiation | ISO |
| GO:0030218 | erythrocyte differentiation | IBA |
| GO:0030889 | negative regulation of B cell proliferation | IMP |
| GO:0031647 | regulation of protein stability | ISS |
| GO:0031647 | regulation of protein stability | ISO |
| GO:0032025 | response to cobalt ion | IEA |
| GO:0032355 | response to estradiol | IEA |
| GO:0032496 | response to lipopolysaccharide | IEA |
| GO:0034349 | glial cell apoptotic process | IMP |
| GO:0035094 | response to nicotine | IEA |
| GO:0035556 | intracellular signal transduction | ISO |
| GO:0042060 | wound healing | IEA |
| GO:0042542 | response to hydrogen peroxide | ISO |
| GO:0043029 | T cell homeostasis | IMP |
| GO:0043065 | positive regulation of apoptotic process | ISO |
| GO:0043065 | positive regulation of apoptotic process | IDA |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0043085 | positive regulation of catalytic activity | IEA |
| GO:0043200 | response to amino acid | IEA |
| GO:0043525 | positive regulation of neuron apoptotic process | ISO |
| GO:0045165 | cell fate commitment | IMP |
| GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | IMP |
| GO:0045786 | negative regulation of cell cycle | IMP |
| GO:0046007 | negative regulation of activated T cell proliferation | IMP |
| GO:0048011 | neurotrophin TRK receptor signaling pathway | ISO |
| GO:0051146 | striated muscle cell differentiation | IEA |
| GO:0051384 | response to glucocorticoid | IEA |
| GO:0051402 | neuron apoptotic process | IMP |
| GO:0051402 | neuron apoptotic process | IGI |
| GO:0051402 | neuron apoptotic process | IDA |
| GO:0061713 | anterior neural tube closure | IMP |
| GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | NAS |
| GO:0071310 | cellular response to organic substance | IDA |
| GO:0071887 | leukocyte apoptotic process | IEA |
| GO:0072734 | cellular response to staurosporine | ISO |
| GO:0097194 | execution phase of apoptosis | ISO |
| GO:0097194 | execution phase of apoptosis | IMP |
| GO:0097194 | execution phase of apoptosis | IDA |
| GO:0097194 | execution phase of apoptosis | IGI |
| GO:1902004 | positive regulation of amyloid-beta formation | ISS |
| GO:1902004 | positive regulation of amyloid-beta formation | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005737 | cytoplasm | IBA |
| GO:0005829 | cytosol | ISO |
| GO:0005829 | cytosol | TAS |
| GO:0031264 | death-inducing signaling complex | ISO |
| GO:0043025 | neuronal cell body | ISO |
| GO:0045121 | membrane raft | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109581 | Apoptosis | IEA |
| R-MMU-109606 | Intrinsic Pathway for Apoptosis | IEA |
| R-MMU-111465 | Apoptotic cleavage of cellular proteins | IEA |
| R-MMU-111469 | SMAC, XIAP-regulated apoptotic response | IEA |
| R-MMU-111471 | Apoptotic factor-mediated response | IEA |
| R-MMU-1280215 | Cytokine Signaling in Immune system | IEA |
| R-MMU-140342 | Apoptosis induced DNA fragmentation | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-193704 | p75 NTR receptor-mediated signalling | IEA |
| R-MMU-2028269 | Signaling by Hippo | IEA |
| R-MMU-204998 | Cell death signalling via NRAGE, NRIF and NADE | IEA |
| R-MMU-205025 | NADE modulates death signalling | IEA |
| R-MMU-264870 | Caspase-mediated cleavage of cytoskeletal proteins | IEA |
| R-MMU-351906 | Apoptotic cleavage of cell adhesion proteins | IEA |
| R-MMU-418889 | Caspase activation via Dependence Receptors in the absence of ligand | IEA |
| R-MMU-449147 | Signaling by Interleukins | IEA |
| R-MMU-449836 | Other interleukin signaling | IEA |
| R-MMU-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | IEA |
| R-MMU-5357801 | Programmed Cell Death | IEA |
| R-MMU-73887 | Death Receptor Signalling | IEA |
| R-MMU-75153 | Apoptotic execution phase | IEA |