| Tag | Content |
|---|---|
| Uniprot ID | P70677; O08668; Q8CHV5; Q9QWI4; |
| Entrez ID | 12367 |
| Genbank protein ID | AAC53196.1; AAH38825.2; CAA73528.1; AAD09504.1; BAA21727.1; AAC52764.1; AAC52768.1; |
| Genbank nucleotide ID | XM_017312543.1; NM_009810.3; NM_001284409.1; |
| Ensembl protein ID | ENSMUSP00000147767; ENSMUSP00000091238; |
| Ensembl nucleotide ID | ENSMUSG00000031628 |
| Gene name | Caspase-3 |
| Gene symbol | Casp3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21515572 |
| Functional description | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. |
| Sequence | MENNKTSVDS KSINNFEVKT IHGSKSVDSG IYLDSSYKMD YPEMGICIII NNKNFHKSTG 60 MSSRSGTDVD AANLRETFMG LKYQVRNKND LTREDILELM DSVSKEDHSK RSSFVCVILS 120 HGDEGVIYGT NGPVELKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETDSGTDE 180 EMACQKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC SMLKLYAHKL EFMHILTRVN 240 RKVATEFESF SLDSTFHAKK QIPCIVSMLT KELYFYH 277 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
