| Tag | Content |
|---|---|
| Uniprot ID | P55213; P70543; P97699; Q62993; |
| Entrez ID | 25402 |
| Genbank protein ID | AAH81854.1; AAB02722.1; AAC52261.1; AAC52765.1; AAB41792.1; |
| Genbank nucleotide ID | NM_012922.2; XM_006253130.3; |
| Ensembl protein ID | ENSRNOP00000014096 |
| Ensembl nucleotide ID | ENSRNOG00000010475 |
| Gene name | Caspase-3 |
| Gene symbol | Casp3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). |
| Sequence | MDNNETSVDS KSINNFETKT IHGSKSMDSG IYLDSSYKMD YPEMGLCIII NNKNFHKSTG 60 MSARNGTDVD AANLRETFMA LKYEVRNKND LTREEIMELM DSVSKEDHSK RSSFVCVILS 120 HGDEGVIFGT NGPVDLKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETDSGTDD 180 DMACQKIPVE ADFLYAYSTA PGYYSWRNSR DGSWFIQSLC AMLKLYAHKL EFMHILTRVN 240 RKVATEFESF SLDATFHAKK QIPCIVSMLT KELYFYH 277 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CASP3 | F1MB04 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | CASP3 | 102177031 | H9B8T7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CASP3 | 100034083 | F7A730 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | CASP3 | 836 | P42574 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Casp3 | 12367 | P70677 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CASP3 | 461669 | Q5IS54 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Casp3 | 25402 | P55213 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0031264 | death-inducing signaling complex |
| GO:0045121 | membrane raft |
| GO:0043025 | neuronal cell body |
| GO:0005634 | nucleus |
| GO:0004190 | aspartic-type endopeptidase activity |
| GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| GO:0004197 | cysteine-type endopeptidase activity |
| GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| GO:0008234 | cysteine-type peptidase activity |
| GO:0005123 | death receptor binding |
| GO:0008233 | peptidase activity |
| GO:0016005 | phospholipase A2 activator activity |
| GO:0002020 | protease binding |
| GO:0044877 | protein-containing complex binding |
| GO:0061713 | anterior neural tube closure |
| GO:0006915 | apoptotic process |
| GO:0007413 | axonal fasciculation |
| GO:0001782 | B cell homeostasis |
| GO:0045165 | cell fate commitment |
| GO:0006974 | cellular response to DNA damage stimulus |
| GO:0071407 | cellular response to organic cyclic compound |
| GO:0071310 | cellular response to organic substance |
| GO:0072734 | cellular response to staurosporine |
| GO:0030218 | erythrocyte differentiation |
| GO:0097194 | execution phase of apoptosis |
| GO:0034349 | glial cell apoptotic process |
| GO:0007507 | heart development |
| GO:0021766 | hippocampus development |
| GO:0035556 | intracellular signal transduction |
| GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress |
| GO:0030216 | keratinocyte differentiation |
| GO:0007611 | learning or memory |
| GO:0071887 | leukocyte apoptotic process |
| GO:0001554 | luteolysis |
| GO:0046007 | negative regulation of activated T cell proliferation |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0030889 | negative regulation of B cell proliferation |
| GO:0045786 | negative regulation of cell cycle |
| GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO:0051402 | neuron apoptotic process |
| GO:0030182 | neuron differentiation |
| GO:0048011 | neurotrophin TRK receptor signaling pathway |
| GO:1902004 | positive regulation of amyloid-beta formation |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0043525 | positive regulation of neuron apoptotic process |
| GO:0016485 | protein processing |
| GO:0006508 | proteolysis |
| GO:0031647 | regulation of protein stability |
| GO:0043200 | response to amino acid |
| GO:0046677 | response to antibiotic |
| GO:0032025 | response to cobalt ion |
| GO:0042493 | response to drug |
| GO:0032355 | response to estradiol |
| GO:0051384 | response to glucocorticoid |
| GO:0009749 | response to glucose |
| GO:0042542 | response to hydrogen peroxide |
| GO:0001666 | response to hypoxia |
| GO:0032496 | response to lipopolysaccharide |
| GO:0010038 | response to metal ion |
| GO:0035094 | response to nicotine |
| GO:0014070 | response to organic cyclic compound |
| GO:0010033 | response to organic substance |
| GO:0009411 | response to UV |
| GO:0009611 | response to wounding |
| GO:0010165 | response to X-ray |
| GO:0007605 | sensory perception of sound |
| GO:0051146 | striated muscle cell differentiation |
| GO:0043029 | T cell homeostasis |
| GO:0042060 | wound healing |