Gene: WDR19

Basic information

Tag Content
Uniprot ID G1SME2
Entrez ID 100352314
Genbank protein ID
Genbank nucleotide ID XM_008275097.2
Ensembl protein ID ENSOCUP00000004084
Ensembl nucleotide ID ENSOCUG00000004716
Gene name WD repeat domain 19
Gene symbol WDR19
Organism Oryctolagus cuniculus
NCBI taxa ID 9986
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MKRVFSLQEK AWHGTPIQFT WQKTSGNYLA VSGADHIVKI FDRHGQKRSE INLPGNCVAM 60
DWDRDGDILA VIAEKSSCIY LWDANTEKTS QLDSGMRDQM SFLLWSKIGS FLAVGTNKGN 120
LLIYNRQTSR KIPVLGKHTK KITCGCWNEE NLLALGGEDR MITISNQEGD TIRQTAVRFE 180
PSDMKFSVMK TGDRTPAAGN TISVVVGKKA LFLFNLNEPD GSVDLEFQQC YGNIVCYSWY 240
GDGYIMIGFS LGVLLVISTH IQEIGQEIFQ TCDHKDNLTS IAVSPTLNKA ATCGDNCIKI 300
HDLAELKDMY AIINLDDENK GLGTLSWTDD GQLLALSTQR GSLHVFLTKL PILGDACSTR 360
IAYLTSLLEV TVANPVEGEP AITVSVDVEP NFVAVGLYHL AVGMNNRAWF YVLGENAVKK 420
LKDVEYLGTV ASICLHSDYA AALFEGKVQL HLIESEMVDA QEERETRLFP AVDDKCRILC 480
HALTADFLIY GTDTGVIQYF YIEDWQFVND YRHPVGVKKL FPDPNGTRLV FIDENSDGFV 540
YCPVNDATYE IPDFSPTIKG VLWENWPLDK GVFIAYDDDK VYTYVFHKDT IQGSKVILAG 600
GTKVPFSHKP LLLYNGELTC QTQSGKINNI YLSTHSFLES LKDAGPNELR QMLAQTLMLK 660
RFSDAWVLCK RLNNHDAWNE LARACLLHME VEFAIRVYRS IGNVGIVMSL EQIKGIEDHN 720
LLAGHLSMFT NDFNQAQDLY LASSCPIAAL EMRRDLQHWD SALQLAKRLA PDQIPFISKE 780
YAIQLEFTGD YVNALAHYEK GITGDNKEHD EVCLAGVAQM SIRMGDIRRG VNQALAHPSR 840
VLKRDCGAIL ESMKQFSEAA QLYEKGLYYD KAASVYIRCK NWVKVGELLP HVSSPKIHLQ 900
YAKAKEADGR YKEAVVAYEN AKQWDSVIRI YLDHLNNPEK AVSVVRDTQS LDGAKMVARF 960
FLQLGDYGSA IQFLVMSKCN NEAFTLAQQH NKMEIYADII GSENTTNEDY QSIALYFEGE 1020
KRHLQAGKFF LLCGQHSRAL KHFLKCPSSE DNMAIEMAIE TVSQAKEELL TRQLIDHLMG 1080
ESDGMPKDAK YLFRLYMALK QYPEAARTAV IIAREEQSAG NYRNAHDVLF SMYAELKSQK 1140
IKIPSEMATN LMILHSYILV KIHMKSGDHM KAARMLIRVA NNISKFPSHI VPILTSTVLK 1200
CHRAGLKNSA FSFAAMLMRP EYRNKIDVKY KKKIEAMVRR PDTSETEEAV TPCPFCEFPL 1260
PECELLCPGC KNNIPYCIAT GRHMLKDDWT VCPHCDFPAL YSELKIMLNT ENTCPMCSER 1320
LNAAQLKKVS DCTQFLQTEV EP 1342

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologWDR19A0A452EI70Capra hircusPredictionMore>>
1:1 orthologWDR1957728Q8NEZ3Homo sapiensPredictionMore>>
1:1 orthologWdr19213081Q3UGF1CPO,CLPMus musculusPublicationMore>>
1:1 orthologWDR19461172H2QPC5Pan troglodytesPredictionMore>>
1:1 orthologWDR19I3LLZ8Sus scrofaPredictionMore>>
1:1 orthologWDR19100352314G1SME2Oryctolagus cuniculusPredictionMore>>
1:1 orthologWdr19305349F1LV01Rattus norvegicusPredictionMore>>
1:1 orthologwdr19E7FGG5Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0030991 intraciliary transport particle A
GO:0031514 motile cilium
GO:0032391 photoreceptor connecting cilium
GO:0000902 cell morphogenesis
GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway
GO:0060271 cilium assembly
GO:0055123 digestive system development
GO:0042471 ear morphogenesis
GO:0031076 embryonic camera-type eye development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0030326 embryonic limb morphogenesis
GO:0008406 gonad development
GO:0001701 in utero embryonic development
GO:0035721 intraciliary retrograde transport
GO:0061055 myotome development
GO:0050877 nervous system process
GO:1903441 protein localization to ciliary membrane
GO:0065003 protein-containing complex assembly
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome
KW-0853 WD repeat

Interpro

InterPro ID InterPro Term
IPR011990 TPR-like_helical_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR040379 WDR19/dyf-2
IPR039468 WDR19_WD40_rpt

PROSITE

PROSITE ID PROSITE Term
PS50294 WD_REPEATS_REGION

Pfam

Pfam ID Pfam Term
PF15911 WD40_3