Gene: GAD2

Basic information

Tag Content
Uniprot ID G1TDS5
Entrez ID 100339011
Genbank protein ID
Genbank nucleotide ID XM_002717305.3
Ensembl protein ID ENSOCUP00000015017
Ensembl nucleotide ID ENSOCUG00000017480
Gene name Glutamate decarboxylase 2
Gene symbol GAD2
Organism Oryctolagus cuniculus
NCBI taxa ID 9986
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MASPGSGFWS FGTEDGSGDP ENPGTARAWC QVAQKFTGGI GNKLCALLYG DTEKPADSGG 60
NQPSRAPARK AACACDQKPC SCPKADVNYA FLHATDLLPA FGGERPTLAF LQEVVDILLQ 120
YVVKSFDRST KVIDFHYPNE LLQEYNWELA EHPQNLEEIL MHCQTTLKYA IKTGHPRYFN 180
QLSTGLDMVG LAADWLTSTA NTNMFTYEIA PVFVLLEYVT LKKMREIIGW PGGSGDGIFS 240
PGGAISNMYA MLIARFKMFP EVKEKGMAAV PRLIAFTSEH SHFSLKKGAA ALGIGTDSVI 300
LIKCDERGKM IPSDLERRIL EAKQKGFVPF LVSATAGTTV YGAFDPLLAV ADICKKYKIW 360
MHVDAAWGGG LLMSRKHKWK LSGVERANSV TWNPHKMMGV PLQCSALLVR EEGLMQSCNQ 420
MHASYLFQQD KHYDLSYDTG DKALQCGRHV DVFKLWLMWR AKGTAGFEAH IDKCLELAEY 480
LYNIIKNREG YEMVFDGKPQ HTNVCFWYVP PSLRVLDDNE ERMSRLSKVA PVIKARMMEY 540
GTTMVSYQPL GDKVNFFRMV ISNPAATHQD IDFLIEEIER LGQDL 585

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGAD2512459F1N6X2Bos taurusPredictionMore>>
1:1 orthologGAD2F1PV66Canis lupus familiarisPredictionMore>>
1:1 orthologGAD2102178638A0A452FGS2Capra hircusPredictionMore>>
1:1 orthologGAD2100055419F7D4X1Equus caballusPredictionMore>>
1:1 orthologGAD22572Q05329Homo sapiensPredictionMore>>
1:1 orthologGad214417P48320CPOMus musculusPublicationMore>>
1:1 orthologGAD2H2Q1R2Pan troglodytesPredictionMore>>
1:1 orthologGAD2A0A2C9F3C1Sus scrofaPredictionMore>>
1:1 orthologGAD2100339011G1TDS5Oryctolagus cuniculusPredictionMore>>
1:1 orthologGad224380Q05683Rattus norvegicusPredictionMore>>
1:1 orthologgad2550403F1R9E8Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0030424 axon
GO:0005737 cytoplasm
GO:0045202 synapse
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0019752 carboxylic acid metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0456 Lyase
KW-0663 Pyridoxal phosphate
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS

PROSITE

PROSITE ID PROSITE Term
PS00392 DDC_GAD_HDC_YDC

Pfam

Pfam ID Pfam Term
PF00282 Pyridoxal_deC