| Tag | Content |
|---|---|
| Uniprot ID | Q05683 |
| Entrez ID | 24380 |
| Genbank protein ID | AAA63488.1 |
| Genbank nucleotide ID | NM_012563.1 |
| Ensembl protein ID | ENSRNOP00000024901 |
| Ensembl nucleotide ID | ENSRNOG00000018200 |
| Gene name | Glutamate decarboxylase 2 |
| Gene symbol | Gad2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the production of GABA. |
| Sequence | MASPGSGFWS FGSEDGSGDP ENPGTARAWC QVAQKFTGGI GNKLCALLYG DSEKPAESGG 60 SVTSRAATRK VACTCDQKPC SCPKGDVNYA LLHATDLLPA CEGERPTLAF LQDVMNILLQ 120 YVVKSFDRST KVIDFHYPNE LLQEYNWELA DQPQNLEEIL THCQTTLKYA IKTGHPRYFN 180 QLSTGLDMVG LAADWLTSTA NTNMFTYEIA PVFVLLEYVT LKKMREIIGW PGGSGDGIFS 240 PGGAISNMYA MLIARYKMFP EVKEKGMAAV PRLIAFTSEH SHFSLKKGAA ALGIGTDSVI 300 LIKCDERGKM IPSDLERRIL EVKQKGFVPF LVSATAGTTV YGAFDPLLAV ADICKKYKIW 360 MHVDAAWGGG LLMSRKHKWK LNGVERANSV TWNPHKMMGV PLQCSALLVR EEGLMQSCNQ 420 MHASYLFQQD KHYDLSYDTG DKALQCGRHV DVFKLWLMWR AKGTTGFEAH IDKCLELAEY 480 LYNIIKNREG YEMVFDGKPQ HTNVCFWFVP PSLRVLEDNE ERMSRLSKVA PVIKARMMEY 540 GTTMVSYQPL GDKVNFFRMV ISNPAATHQD IDFLIEEIER LGQDL 585 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GAD2 | 512459 | F1N6X2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GAD2 | F1PV66 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | GAD2 | 102178638 | A0A452FGS2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GAD2 | 100055419 | F7D4X1 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | GAD2 | 2572 | Q05329 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gad2 | 14417 | P48320 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GAD2 | H2Q1R2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | GAD2 | A0A2C9F3C1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GAD2 | 100339011 | G1TDS5 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gad2 | 24380 | Q05683 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | gad2 | 550403 | F1R9E8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031225 | anchored component of membrane |
| GO:0030424 | axon |
| GO:0005737 | cytoplasm |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005829 | cytosol |
| GO:0000139 | Golgi membrane |
| GO:0060077 | inhibitory synapse |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0042734 | presynaptic membrane |
| GO:0045202 | synapse |
| GO:0030672 | synaptic vesicle membrane |
| GO:0016595 | glutamate binding |
| GO:0004351 | glutamate decarboxylase activity |
| GO:0044877 | protein-containing complex binding |
| GO:0030170 | pyridoxal phosphate binding |
| GO:0007268 | chemical synaptic transmission |
| GO:0006540 | glutamate decarboxylation to succinate |
| GO:0042136 | neurotransmitter biosynthetic process |
| GO:0042493 | response to drug |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0965 | Cell junction |
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-0963 | Cytoplasm |
| KW-0968 | Cytoplasmic vesicle |
| KW-0210 | Decarboxylase |
| KW-0903 | Direct protein sequencing |
| KW-0333 | Golgi apparatus |
| KW-0449 | Lipoprotein |
| KW-0456 | Lyase |
| KW-0472 | Membrane |
| KW-0530 | Neurotransmitter biosynthesis |
| KW-0564 | Palmitate |
| KW-0597 | Phosphoprotein |
| KW-0663 | Pyridoxal phosphate |
| KW-1185 | Reference proteome |
| KW-0770 | Synapse |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00392 | DDC_GAD_HDC_YDC |
| Pfam ID | Pfam Term |
|---|---|
| PF00282 | Pyridoxal_deC |