| Tag | Content |
|---|---|
| Uniprot ID | K7D393; A0A2J8QNV6; |
| Entrez ID | 458763 |
| Genbank protein ID | JAA34109.1 |
| Genbank nucleotide ID | XM_016938971.1 |
| Ensembl protein ID | ENSPTRP00000072057 |
| Ensembl nucleotide ID | ENSPTRG00000014257 |
| Gene name | MORC family CW-type zinc finger 2 |
| Gene symbol | MORC2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAFTNYSSLN RAQLTFEYLH TNSTTHEFLF GALAELVDNA RDADATRIDI YAERREDLRG 60 GFMLCFLDDG AGMDSSDAAS VIQFGKSAKR TPESTQIGQY GNGLKSGSMR IGKDFILFTK 120 KEDTMTCLFL SRTFHEEEGI DEVIVPLPTW NARTREPVTD NVEKFAIETE LIYKYSPFRT 180 EEEVMTQFMK IPGDSGTLVI IFNLKLMDNG EPELDIISNP RDIQMAETSP EGTKPERRSF 240 RAYAAVLYID PRMRIFIHGH KVQTKRLSCC LYKPRMYKYT SSRFKTRAEQ EVKKAEHVAR 300 IAEEKAREAE SKARTLEVRL GGDLTRDSRV MLRQVQNRAI TLRREADVKK RIKEAKQRAL 360 KEPKELNFVF GVNIEHRDLD GMFIYNCSRL IKMYEKVGPQ LEGGMACGGV VGVVDVPYLV 420 LEPTHNKQDF ADAKEYRHLL RAMGEHLAQY WKDIAIAQRG IIKFWDEFGY LSANWNQPPS 480 SELRYKRRRA MEIPTTIQCD LCLKWRTLPF QLSSVEKDYP DTWVCSMNPD PEQDRCEASE 540 QKQKVPLGTF RKDMKTQEEK QKQLTEKIRQ QQEKLEALQK TTPIRSQADL KKLPLEVTTR 600 PSTEEPVRRP QRPRSPPLPA VIRNAPSRPP SLPTPRPASQ PRKAPVISST PKLPALAARE 660 EASTSRLLQP PEAPRKPANT LVKTASRPVP LVQQLSPSLL PNSKSPREVP SPKVIKTPVV 720 KKTESPIKLS PATPSRKRSV AVSDEEEVEE EAERRKERCK RGRFVVKEEK KDSNELSDSA 780 GEEDSADLKR AQKDKGLHVE VRVNREWYTG RVTAVEVGKH VVRWKVKFDY VPTDTTPRDR 840 WVEKGSEDVR LMKPPSPEHQ SLDTQQEGGE EEVGPVAQQA IAVAEPSTSE CLRIEPDTTA 900 LSTNHETIDL LVQILRNCLR YFLPPSFPIS KKQLSAMNSD ELISFPLKEY FKQYEVGLQN 960 LCNSYQSRAD SRAKASEESL RTSERKLRET EEKLQKLRTN IVALLQKVQE DIDINTDDEL 1020 DAYIEDLITK GD 1032 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MORC2 | 486358 | E2RBF9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MORC2 | A0A452FN52 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MORC2 | 22880 | Q9Y6X9 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Morc2a | 74522 | Q69ZX6 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MORC2 | 458763 | K7D393 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MORC2 | F1RPD9 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Morc2 | 289736 | A0A0G2JWF7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | morc2 | 445488 | Q68EG7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0000792 | heterochromatin |
| GO:0016363 | nuclear matrix |
| GO:0005654 | nucleoplasm |
| GO:0005524 | ATP binding |
| GO:0016887 | ATPase activity |
| GO:0003682 | chromatin binding |
| GO:0000287 | magnesium ion binding |
| GO:0042803 | protein homodimerization activity |
| GO:0008270 | zinc ion binding |
| GO:0006974 | cellular response to DNA damage stimulus |
| GO:0006338 | chromatin remodeling |
| GO:0045814 | negative regulation of gene expression, epigenetic |
| GO:0045869 | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate |
| GO:0090309 | positive regulation of methylation-dependent chromatin silencing |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51050 | ZF_CW |