Gene: Morc2a

Basic information

Tag Content
Uniprot ID Q69ZX6; Q5QNQ7; Q6P547;
Entrez ID 74522
Genbank protein ID AAH63082.1; BAD32320.1;
Genbank nucleotide ID XM_011243776.2; NM_001159288.1;
Ensembl protein ID ENSMUSP00000091087; ENSMUSP00000094176;
Ensembl nucleotide ID ENSMUSG00000034543
Gene name ATPase MORC2A
Gene symbol Morc2a
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 27933520
Functional description Essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark (PubMed:29728365). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. During DNA damage response, regulates chromatin remodeling through ATP hydrolysis (By similarity). During DNA damage response, may regulate chromatin remodeling through ATP hydrolysis (By similarity).
Sequence
MAFTNYSSLN RAQLTFEYLH TNSTTHEFLF GALAELVDNA RDADATRIDI YAERREDLRG 60
GFMLCFLDDG AGMDPSDAAS VIQFGKSAKR TPESTQIGQY GNGLKSGSMR IGKDFILFTK 120
KEDTMTCLFL SRTFHEEEGI DEVIVPLPTW NARTREPITD NVEKFAIETE LVYKYSPFHT 180
EEQVMNQFMK IPGNSGTLVI IFNLKLMDNG EPELDIISNP KDIQMAETSP EGTKPERRSF 240
RAYAAVLYID PRMRIFIHGH KVQTKRLSCC LYKPRMYKYT SSRFKTRAEQ EVKKAEHVAR 300
IAEEKAREAE SKARTLEVRM GGDLTRDSRV MLRQVQNTAI TLRREADVKK RIKDAKQRAL 360
KEPKELNFVF GVNIEHRDLD GMFIYNCSRL IKMYEKVGPQ LEGGMACGGV VGVVDVPYLV 420
LEPTHNKQDF ADAKEYRHLL RAMGEHLAQY WKDIAIAQRG IIKFWDEFGY LSANWNQPPS 480
SELRFKRRRA MEIPTTIQCD LCLKWRTLPF QLSSVETDYP DTWVCSMNPD PEQDRCEASE 540
QKQKVPLGTL KKDPKTQEEK QKQLTEKIRQ QQEKLEALQK TTPIRSQADL KKLPLEVTTR 600
PIEEPVRRPQ RPRSPPLPAV IKNAPSRPPS IQTPRPSTQL RKTSVISLPK PPTTAARGET 660
STSRLLQPTE APRKPANPPI KTVPRPTPPV HTPPLSLIPS SKSLREVPAQ KAIKTPVVKK 720
PEPPVKQSVA TSGRKRSLAV SDEEEAEEEA EKRRERCKRG KLAVKEEKKE ANELSDSAGE 780
DHPAELRKAQ KDKGLHVEVR VNREWYTGRV TAVEVGKNAV RWKVKFDYVP TDTTPRDRWV 840
EKGSEDVRLM KPPSPEHQSP DTQQEGGEEE EAMVARQAVA LPEPSTSDGL PIEPDTTATS 900
PSHETIDLLV QILRNCLRYF LPPSFPISKK ELSVMNSEEL ISFPLKEYFK QYEVGLQNLC 960
HSYQSRADSR AKASEESLRT SEKKLRETEE KLQKLRTNIV ALLQKVQEDI DINTDDELDA 1020
YIEDLITKGD

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMORC2486358E2RBF9Canis lupus familiarisPredictionMore>>
1:1 orthologMORC2A0A452FN52Capra hircusPredictionMore>>
1:1 orthologMORC222880Q9Y6X9Homo sapiensPredictionMore>>
1:1 orthologMorc2a74522Q69ZX6CPOMus musculusPublicationMore>>
1:1 orthologMORC2458763K7D393Pan troglodytesPredictionMore>>
1:1 orthologMORC2F1RPD9Sus scrofaPredictionMore>>
1:1 orthologMorc2289736A0A0G2JWF7Rattus norvegicusPredictionMore>>
1:1 orthologmorc2445488Q68EG7Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000287 magnesium ion bindingISS
GO:0000287 magnesium ion bindingISO
GO:0003682 chromatin bindingISS
GO:0003682 chromatin bindingISO
GO:0005515 protein bindingIPI
GO:0005524 ATP bindingISS
GO:0005524 ATP bindingISO
GO:0008270 zinc ion bindingISS
GO:0008270 zinc ion bindingISO
GO:0016887 ATPase activityISS
GO:0016887 ATPase activityISO
GO:0042393 histone bindingIMP
GO:0042803 protein homodimerization activityISS
GO:0042803 protein homodimerization activityISO

GO:Biological Process

GO ID GO Term Evidence
GO:0006338 chromatin remodelingISS
GO:0006338 chromatin remodelingISO
GO:0006974 cellular response to DNA damage stimulusISS
GO:0006974 cellular response to DNA damage stimulusISO
GO:0045814 negative regulation of gene expression, epigeneticISS
GO:0045814 negative regulation of gene expression, epigeneticISO
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediateISS
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediateISO
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediateIMP
GO:0090309 positive regulation of methylation-dependent chromatin silencingISS
GO:0090309 positive regulation of methylation-dependent chromatin silencingISO
GO:0090309 positive regulation of methylation-dependent chromatin silencingIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0000792 heterochromatinISS
GO:0000792 heterochromatinISO
GO:0005634 nucleusISS
GO:0005634 nucleusISO
GO:0005634 nucleusIBA
GO:0005654 nucleoplasmISO
GO:0005737 cytoplasmISS
GO:0005737 cytoplasmISO
GO:0005829 cytosolISO
GO:0016363 nuclear matrixISS
GO:0016363 nuclear matrixISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1430728 MetabolismIEA
R-MMU-556833 Metabolism of lipidsIEA
R-MMU-75105 Fatty acyl-CoA biosynthesisIEA
R-MMU-8978868 Fatty acid metabolismIEA

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0067 ATP-binding
KW-0158 Chromosome
KW-0175 Coiled coil
KW-0963 Cytoplasm
KW-0378 Hydrolase
KW-1017 Isopeptide bond
KW-0460 Magnesium
KW-0479 Metal-binding
KW-0547 Nucleotide-binding
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0832 Ubl conjugation
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR036890 HATPase_C_sf
IPR041006 Morc_S5
IPR011124 Znf_CW

PROSITE

PROSITE ID PROSITE Term
PS51050 ZF_CW

Pfam

Pfam ID Pfam Term
PF17942 Morc6_S5
PF07496 zf-CW

Protein-miRNA interaction