Gene: NDST1

Basic information

Tag Content
Uniprot ID M3V841
Entrez ID
Genbank protein ID JAA74222.1; HDB00584.1;
Genbank nucleotide ID
Ensembl protein ID ENSSSCP00000033060
Ensembl nucleotide ID ENSSSCG00000032731
Gene name Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2
Gene symbol NDST1
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MPVPARLRRL CRHVSPQAVL FLLFVFCLFS VFVSAYYLYG WKRGLEPSAD APEPDCGDPP 60
PVAPSRLLPL KPVQAAAPSR TDPLVLVFVE SLYSQLGQEV VAILESSRFK YRTEIAPGKG 120
DMPTLTDKGR GRFALIIYEN ILKYVNLDAW NRELLDKYCV AYGVGIIGFF KANENSLLSA 180
QLKGFPLFLH SNLGLKDCSI NPKSPLLYVT RPSEVDKGVL PGEDWTVFQW NHSTYEPVLL 240
AKTRSAESIP HLGADAGLHA ALHATVVQDL GLHDGIQRVL FGNNLSFWLH KLVFVDAVAF 300
LTGKRLALPL ERYILVDIDD IFVGKEGTRM KVEDVKALFE TQNELRTHIP NFTFNLGYSG 360
KFFHTGTDAE DAGDDLLLSY VEEFWWFPHM WSHMQPHLFH NQSVLAEQMA LNKKFAVEHG 420
IPTDMGYAVA PHHSGVYPVH VQLYEAWKQV WSIRVTSTEE YPHLKPARHR RGFIHDGIMV 480
LPRQTCGLFT HTIFHNEYPG GSGELDKIIH GGELFLTVLL NPISIFMTHL SNYGNDRLGL 540
YTFKHLARFL HSWTNLRLQT LPPVQLAQKY FQIFSEEKDP LWQDPCEDKR HKDIWSKEKT 600
CDRFPKLLII GPQKTGTTAL YLFLGLHPDL SSNYPSSETF EEIQFFNGHN YHKGIDWYMD 660
FFPIPSNTTS DFYFEKSANY FDSDVAPRRA AALLPKAKVL TILINPADRA YSWYQHQRAH 720
DDPAALRYTF HEVITAGPDA SLKLRALQNR CLVPGWYATH LERWLGAFHA NQILVLDGKL 780
LRTEPARVMD TVQKFLGVTN TIDYHKTLAF DPKKGFWCQL LEGGKTKCLG RSKGRKYPDM 840
DPDSRAFLRD YYRDHNIELS KLLYKMGQTL PTWLREELQN TR 882

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNDST1514172E1BCG5Bos taurusPredictionMore>>
1:1 orthologNDST1102174299A0A452EZE5Capra hircusPredictionMore>>
1:1 orthologNDST13340P52848Homo sapiensPredictionMore>>
1:1 orthologNdst115531Q3UHN9CPOMus musculusPublicationMore>>
1:1 orthologNDST1462194H2R584Pan troglodytesPredictionMore>>
1:1 orthologNDST1M3V841Sus scrofaPredictionMore>>
1:1 orthologNDST1100344304G1T1F7Oryctolagus cuniculusPredictionMore>>
1:1 orthologNdst129633Q02353Rattus norvegicusPredictionMore>>
1:1 orthologndst1b570459A0A0R4IR84Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016021 integral component of membrane
GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0019213 deacetylase activity
GO:0035904 aorta development
GO:0003279 cardiac septum development
GO:0060976 coronary vasculature development
GO:0048702 embryonic neurocranium morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0030900 forebrain development
GO:0030203 glycosaminoglycan metabolic process
GO:0030901 midbrain development
GO:0000271 polysaccharide biosynthetic process
GO:0043410 positive regulation of MAPK cascade
GO:0045880 positive regulation of smoothened signaling pathway
GO:0006477 protein sulfation
GO:0007585 respiratory gaseous exchange by respiratory system

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0472 Membrane
KW-1185 Reference proteome
KW-0808 Transferase
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR021930 Heparan_SO4_deacetylase
IPR037359 NST/OST
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF12062 HSNSD
PF00685 Sulfotransfer_1