Gene: Mnt

Basic information

Tag Content
Uniprot ID O08789; P97349; Q6GTJ3;
Entrez ID 17428
Genbank protein ID AAH54534.1; EDL12780.1; CAA68878.1; AAB38687.1;
Genbank nucleotide ID NM_010813.3
Ensembl protein ID ENSMUSP00000000291
Ensembl nucleotide ID ENSMUSG00000000282
Gene name Max-binding protein MNT
Gene symbol Mnt
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 15028671
Functional description Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Sequence
MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEREREREQ EQKRASNLAR LAHALPVEEP 60
RIEAPPLPLS PPAPPPAPPP PLATPAPLTV IPIPVVTNSP QSLPPPPPLP PAAQPLPLAP 120
RQPALVSTPG LSIKEPVTLP TRPQVPTPAP LLPDAKTTVA PTGSPKPLQP LPAPILTIAP 180
HPGVQPQLAP QQPPPPTLGT LKLAPAEEAK SSEQKKRPGG IGTREVHNKL EKNRRAHLKE 240
CFETLKRNIP NVDDKKTSNL SVLRTALRYI QSLKRKEKEY EHEMERLARE KIATQQRLAE 300
LKHELSQWMD VLEIDRVLRQ TGQPEDDQAS TSTASEGEDN VDEEMEGDRA GLGPPKLNHR 360
PQPELLKSAL PTPSTAPAPL PTHPHPHPHP VALSPAHLPV QQQQPPQQKT PLPAPPPPPA 420
TPTQTLVPAP AHLVATAGGG STVIAHTATT HASVIQTVNH VLQGPGGKHI AHIAPSAPSP 480
AVQLAPATPP IGHITVHPAT LNHVAHLGSQ LPLYPQPVAV SQPVAVSHIA HTLSHQQVNG 540
TAGLGPPATV MAKPAVGAQV VHHPQLVGQT VLNPVTMVTM PSFPVSTLKL A 591

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMNT618576E1BCU5Bos taurusPredictionMore>>
1:1 orthologMNTE2QY39Canis lupus familiarisPredictionMore>>
1:1 orthologMNTA0A452FE74Capra hircusPredictionMore>>
1:1 orthologMNT4335Q99583Homo sapiensPredictionMore>>
1:1 orthologMnt17428O08789CPOMus musculusPublicationMore>>
1:1 orthologMNTA0A2I3RB25Pan troglodytesPredictionMore>>
1:1 orthologMNTA0A287AGL3Sus scrofaPredictionMore>>
1:1 orthologMNT100354631G1TAW6Oryctolagus cuniculusPredictionMore>>
1:1 orthologMnt287521A0A0U1RRY7Rattus norvegicusPredictionMore>>
1:1 orthologmntbF1QBK5Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA bindingISO
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specificISO
GO:0003677 DNA bindingIDA
GO:0003682 chromatin bindingIDA
GO:0003700 DNA-binding transcription factor activityIMP
GO:0005515 protein bindingIPI
GO:0046983 protein dimerization activityIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIISO
GO:0006355 regulation of transcription, DNA-templatedIMP
GO:0007569 cell agingIMP
GO:0051726 regulation of cell cycleIMP
GO:2001234 negative regulation of apoptotic signaling pathwayIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusIC
GO:0005654 nucleoplasmISO

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0238 DNA-binding
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0678 Repressor
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf

PROSITE

PROSITE ID PROSITE Term
PS50888 BHLH

Pfam

Pfam ID Pfam Term
PF00010 HLH

Protein-protein interaction

Protein-miRNA interaction