| Tag | Content |
|---|---|
| Uniprot ID | P49919; G3UW61; |
| Entrez ID | 12577 |
| Genbank protein ID | EDL18208.1; AAC52186.1; AAA85096.1; |
| Genbank nucleotide ID | NM_009876.4; NM_001161624.1; XM_006508471.3; |
| Ensembl protein ID | ENSMUSP00000037302; ENSMUSP00000128828; |
| Ensembl nucleotide ID | ENSMUSG00000037664 |
| Gene name | Cyclin-dependent kinase inhibitor 1C |
| Gene symbol | Cdkn1c |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5, E17.5 |
| Data sources | Manually collected |
| Reference | 9136926; 9144284; |
| Functional description | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. |
| Sequence | MGMSDVYLRS RTAMERLASS DTFPVIARSS ACRSLFGPVD HEELGRELRM RLAELNAEDQ 60 NRWDFNFQQD VPLRGPGRLQ WMEVDSESVP AFYRETVQVG RCRLQLGPRP PPVAVAVIPR 120 SGPPAGEAPD GLEEAPEQPP SAPASAVVAE PTPPATPAPA SDLTSDPIPE VTLVATSDPT 180 PDPIPDANPD VATRDGEEQV PEQVSEQGEE SGAEPGDELG TEPVSEQGEE QGAEPVEEKD 240 EEPEEEQGAE PVEEQGAEPV EEQNGEPVEE QDENQEQRGQ ELKDQPLSGI PGRPAPGTAA 300 ANANDFFAKR KRTAQENKAS NDVPPGCPSP NVAPGVGAVE QTPRKRLR 348 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CDKN1C | F1N786 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | CDKN1C | A0A452ECM9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | CDKN1C | 1028 | P49918 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Cdkn1c | 12577 | P49919 | CPO | E14.5, E17.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | CDKN1C | A0A2I3TME0 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | CDKN1C | A0A287A9C4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Cdkn1c | 246060 | Q69DC1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IGI |
| GO:0001501 | skeletal system development | IMP |
| GO:0001822 | kidney development | IMP |
| GO:0001890 | placenta development | IMP |
| GO:0001890 | placenta development | IGI |
| GO:0007050 | cell cycle arrest | IEA |
| GO:0007096 | regulation of exit from mitosis | IGI |
| GO:0007568 | aging | IMP |
| GO:0030099 | myeloid cell differentiation | IGI |
| GO:0030325 | adrenal gland development | IMP |
| GO:0035264 | multicellular organism growth | IMP |
| GO:0042326 | negative regulation of phosphorylation | IDA |
| GO:0042326 | negative regulation of phosphorylation | IBA |
| GO:0042551 | neuron maturation | IMP |
| GO:0043010 | camera-type eye development | IMP |
| GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | IBA |
| GO:0045930 | negative regulation of mitotic cell cycle | IBA |
| GO:0055123 | digestive system development | IMP |
| GO:0060065 | uterus development | IMP |
| GO:0060669 | embryonic placenta morphogenesis | IMP |
| GO:0071514 | genetic imprinting | IMP |
| GO:1902746 | regulation of lens fiber cell differentiation | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1640170 | Cell Cycle | IEA |
| R-MMU-187577 | SCF(Skp2)-mediated degradation of p27/p21 | IEA |
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-2262752 | Cellular responses to stress | IEA |
| R-MMU-2559582 | Senescence-Associated Secretory Phenotype (SASP) | IEA |
| R-MMU-2559583 | Cellular Senescence | IEA |
| R-MMU-2559586 | DNA Damage/Telomere Stress Induced Senescence | IEA |
| R-MMU-3700989 | Transcriptional Regulation by TP53 | IEA |
| R-MMU-453279 | Mitotic G1 phase and G1/S transition | IEA |
| R-MMU-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | IEA |
| R-MMU-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | IEA |
| R-MMU-69202 | Cyclin E associated events during G1/S transition | IEA |
| R-MMU-69206 | G1/S Transition | IEA |
| R-MMU-69231 | Cyclin D associated events in G1 | IEA |
| R-MMU-69236 | G1 Phase | IEA |
| R-MMU-69242 | S Phase | IEA |
| R-MMU-69278 | Cell Cycle, Mitotic | IEA |
| R-MMU-69563 | p53-Dependent G1 DNA Damage Response | IEA |
| R-MMU-69580 | p53-Dependent G1/S DNA damage checkpoint | IEA |
| R-MMU-69615 | G1/S DNA Damage Checkpoints | IEA |
| R-MMU-69620 | Cell Cycle Checkpoints | IEA |
| R-MMU-69656 | Cyclin A:Cdk2-associated events at S phase entry | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| R-MMU-8953897 | Cellular responses to external stimuli | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF02234 | CDI |