Gene: Eif2b3

Basic information

Tag Content
Uniprot ID P70541; Q6IN08;
Entrez ID 171145
Genbank protein ID AAH72507.1; AAC52788.1;
Genbank nucleotide ID XM_006238630.3; NM_133609.2;
Ensembl protein ID ENSRNOP00000024841
Ensembl nucleotide ID ENSRNOG00000018375
Gene name Translation initiation factor eIF-2B subunit gamma
Gene symbol Eif2b3
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Sequence
MEFQAVVMAV GGGSRMTDLT SSIPKPLLPV GNKPLIWYPL NLLERVGFEE VIVVTTKDVQ 60
KALCAEFKMK LKPDIVCIPD EADMGTADSL RHIYPKLKTD VLVLGCDLIT DVALHEVVDL 120
FRAYDASLAM LMRKGQESTE PVPGQKGKKK TVEQRDFIGV DSTGKRLLFM ANEADLDEEL 180
VIKGSILQKH PRIHFQTGLV DAHLYCLKKY VVDFLMENKS ITSIRSELIP YLVRKQFSSA 240
SSQQRQEDKE EDLKKKEPKS LDIYSFIKKD NTLTLAPYDA CWNAFRRDKW EDLSRSQVRC 300
YVHIMKEGLC SRVSTLGLYM EANRQVPKLL SVLCPEESMI HPSAQIANKH LIGADSLIGS 360
DTQVGEKSSI KRSVIGSSCV IRDRVTVTNC LLMNSVTVEE GSSIHGSVIC NNAVVEAGAE 420
IRDCLIGSGQ RIEAKAKRMN EVIVGNDQLM EI 452

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologEIF2B3475379E2RBJ1Canis lupus familiarisPredictionMore>>
1:1 orthologEIF2B3102187733A0A452ERT4Capra hircusPredictionMore>>
1:1 orthologEIF2B3100065686F6V4Y8Equus caballusPredictionMore>>
1:1 orthologEIF2B38891Q9NR50Homo sapiensPublicationMore>>
1:1 orthologEif2b3108067B1AUN2Mus musculusPredictionMore>>
1:1 orthologEIF2B3H2R941Pan troglodytesPredictionMore>>
1:1 orthologEIF2B3100348406G1T3H5Oryctolagus cuniculusPredictionMore>>
1:1 orthologEif2b3171145P70541Rattus norvegicusPredictionMore>>
1:1 orthologeif2b3394049Q7ZTY5Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0016779 nucleotidyltransferase activity
GO:0003743 translation initiation factor activity
GO:0002183 cytoplasmic translational initiation
GO:0021766 hippocampus development
GO:0014003 oligodendrocyte development
GO:0009749 response to glucose
GO:0009408 response to heat
GO:0043434 response to peptide hormone
GO:0050852 T cell receptor signaling pathway
GO:0006412 translation
GO:0006413 translational initiation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0396 Initiation factor
KW-0597 Phosphoprotein
KW-0648 Protein biosynthesis
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF00483 NTP_transferase