Gene: cdon

Basic information

Tag Content
Uniprot ID Q1L8D0
Entrez ID 280652
Genbank protein ID AAI33077.1
Genbank nucleotide ID XM_009293823.2; NM_001081628.1;
Ensembl protein ID ENSDARP00000081773
Ensembl nucleotide ID ENSDARG00000061328
Gene name Cell adhesion molecule-related/down-regulated by oncogenes
Gene symbol cdon
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MEDGGLRLLS AVLCVCHTLL LNCPTVLSFS FRAEPLSAIL KQGSSVHLHC TTHPATARIS 60
WLFQGQPLDP SHHSGVELSQ DSLSLSNLQP ALTGSYQCSA RSETGSIISR HARVTIADIE 120
EFAETHRRSF TVNKGDTAVI ECPLPRSNPP ALPRFRIRGK WLEQSTDEYL ILPSGNLQIV 180
SVSSEHQGMY KCGAYNPLTR ETRVEAHGTK LLVKDSESSS PVRIVYPITP RSLTVDQSGS 240
LTLECVVSGS LSSKVKWMKN GAELSLSSKR MLSHSNLVLN DIQPGDGGHY SCSVPTDRGA 300
VVSVNYTVNV LAHVSILRGL SDQAAVAGSS VRFTCAASGN PTPNITWLLN AAPLSSSPRL 360
KISGTSLLIS STTLQDQGIY QCMFDNGISS AQSTGRLSIQ SEPQSSSISA VPVKTQPSVH 420
PIQSDEGDEL FLSMGEAALG ETVGPPTERI GDRPTPEAPI IISPPQTHKP NMYDLEWRAG 480
RDWGIAIIAY FVKYRKVDDM GNVVGSWHTV RVPGSEKSLP LSELEPSSLY EVLMVARSAA 540
GEGQPAMLTF RTGKERASPN KNPSKAPIVS LPEKTPEDKT TNTYYGVVIH DRVPEAPDRP 600
TISMATESSV YVTWIPRANG GSPITAFRVE YRKQGRNGDW IIAADNISPL KLSVEVRNLE 660
PGSTYRFRVI AMNNYGESPA SATSRPYQVS MSSSPVSNRP VTGPHISSTD AVSDTQILLR 720
WTYTPSSNNN TPIQGFYIYY RPTDSDNDSD YKKDVVEGFK FWHMIGELQP ETSYDIKMQC 780
YNDGGESEYS NVMICETKAR QPPGVPSLRP ITPPGFYPAD TPSQPGGLLY LIVGCVLGVM 840
VLILLVFIVM CLWRNRQQNS MHKYDPPNYI YQSAEMNGHV LDYSALPGSS HVNGSVHTGC 900
GHTAPMMPQT CHHLHHKLPN GLALLNGSGG LYPAGHPHAH DTSLHQNNME YEHPSPHHLH 960
NGGGIYTALP QNDSSDCMSC QNFCNNNRCY TKTNGTFSGG TLPLMHRVAA RQPDGLEMMP 1020
LNPILSRCHG RDSPQLNGCQ DRDSVQQAEE GNVPPLSHNS PCLPVETKSS LEQQRGVQQV 1080
QHEDSEGPVV CWERLGLDLD CKEKTAWIST GSLTGDLIQP TVQEI 1125

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCDON536011E1BHG3Bos taurusPredictionMore>>
1:1 orthologCDON102188923A0A452DT38Capra hircusPredictionMore>>
1:1 orthologCDON50937Q4KMG0Homo sapiensPredictionMore>>
1:1 orthologCdon57810Q32MD9CPOMus musculusPublicationMore>>
1:1 orthologCDON451650H2Q530Pan troglodytesPredictionMore>>
1:1 orthologCDONI3LGV0Sus scrofaPredictionMore>>
1:1 orthologCDONG1T3Q0Oryctolagus cuniculusPredictionMore>>
1:1 orthologCdon50938G3V7K7Rattus norvegicusPredictionMore>>
1:1 orthologcdon280652Q1L8D0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005887 integral component of plasma membrane
GO:0048598 embryonic morphogenesis
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045663 positive regulation of myoblast differentiation
GO:0045664 regulation of neuron differentiation
GO:0007224 smoothened signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0393 Immunoglobulin domain
KW-0472 Membrane
KW-1185 Reference proteome
KW-0677 Repeat
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR032983 CDO
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

PROSITE

PROSITE ID PROSITE Term
PS50853 FN3
PS50835 IG_LIKE

Pfam

Pfam ID Pfam Term
PF00041 fn3
PF07679 I-set