Gene: Cdon

Basic information

Tag Content
Uniprot ID Q32MD9; E9QKV9; O88971;
Entrez ID 57810
Genbank protein ID AAC43031.1; AAI09177.1;
Genbank nucleotide ID XM_006510507.3; XM_006510511.3; XM_006510510.3; XM_006510508.3; XM_011242581.2; NM_021339.2; XM_006510509.3;
Ensembl protein ID ENSMUSP00000113977; ENSMUSP00000045547;
Ensembl nucleotide ID ENSMUSG00000038119
Gene name Cell adhesion molecule-related/down-regulated by oncogenes
Gene symbol Cdon
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 21183473
Functional description Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3.
Sequence
MHPDLGPLWT LLYVLVILCS SVSSDLAPYF ISEPLSAVQK LGRPVVLHCS AKPVTARISW 60
LHNGKRLDRN TEQIKIHRGT LTILSLNPSL SGCYQCVANN SVGAVVSGPA TVSAAALGDF 120
DSSTMHVITA EEKNTGFIGC RVPESNPKAE VRYKIRGKWL KHSTGNYIIL PSGNLQVLNV 180
SSKDKGSYKC AAYNPVTSEL KVEPTGRKLL VSRPSSNGFH ILHPALSQAL AVLPHSPVTL 240
ECVVSGVPAS QVYWLKDGQD AVAGSNWRRL YSHLATASID PADSGNYSCV VGNKSGDVKH 300
VTYMVNVLEH ASISKGLHDQ KVSLGATVHF TCDVHGNPAP NRTWFHNAQP IHPSSRHLTE 360
GNVLKITRVV MEDSGLYQCV ADNGIGFMQS TGRLQIEQDS GWKPVIVTAP ANIEVMDGDF 420
VTLSCNATGV PVPVIHWYGR HGLITSHPSQ VLRSKPRKSH LFRPGDLDLE PVYLIMSQAG 480
SSSLSIQAVT LEHAGKYTCE ATNKHGSTQS EAFLTVVPFE TNTKAESVTP SEASQNDERD 540
PQDGSESSLL NLFPVKVHPS GVELPAERNA SVPDAPNILS PPQTHMPDTY NLVWRAGRDG 600
GMPINAYFVK YRKLDDGSGA VGSWHTVRVP GSENELHLTE LEPSSLYEVL MVARSAVGEG 660
QPAMLTFRTS KEKMASSKNT QASFPPVGVP KRPVTAEASN SNFGVVLTDS SRHSGVPEAP 720
DRPTISMASE TSVYVTWIPR ANGGSPITAF KVEYKRMRTS DWLVAAEDIP PSKLSVEVRS 780
LEPGSIYKFR VIAINHYGES FRSSASRPYQ VAGFPNRFSN RPITGPHIAY TEAVSDTQIM 840
LKWTYVPSSN NNTPIQGFYI YYRPTDSDND SDYKRDVVEG SKQWHTIGHL QPETSYDIKM 900
QCFNEGGESE FSNVMICETK VKRVPGASDY PVKELSTPPS SSGNAGNVGP ATSPARSSDM 960
LYLIVGCVLG VMVLILMVFI ALCLWKSRQQ STIQKYDPPG YLYQGSEING QMVEYTTLSG 1020
AARINGSVHG GFLSNGCSHL HHKGPSGVNG TLSGNINGGL YSAHTNSLTR ACVEFEHPHH 1080
LVNSGGVYTA VPQMDPLECI NCRNCRNNNR CFTKTNSPLP VVPVVASYPQ GGLEMKPLNA 1140
MKVPVCPAST VPDHGQLPDD CVKDSVAPIP TQHTCCQDNI SDINSDSTED TAEFSRGDSS 1200
GHSEAEDKVF SWNPLILSPV LEDCGEKTAR SPPGPPLDGL SVVLQQAQET

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCDON536011E1BHG3Bos taurusPredictionMore>>
1:1 orthologCDON102188923A0A452DT38Capra hircusPredictionMore>>
1:1 orthologCDON50937Q4KMG0Homo sapiensPredictionMore>>
1:1 orthologCdon57810Q32MD9CPOMus musculusPublicationMore>>
1:1 orthologCDON451650H2Q530Pan troglodytesPredictionMore>>
1:1 orthologCDONI3LGV0Sus scrofaPredictionMore>>
1:1 orthologCDONG1T3Q0Oryctolagus cuniculusPredictionMore>>
1:1 orthologCdon50938G3V7K7Rattus norvegicusPredictionMore>>
1:1 orthologcdon280652Q1L8D0Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI

GO:Biological Process

GO ID GO Term Evidence
GO:0001708 cell fate specificationIGI
GO:0001934 positive regulation of protein phosphorylationIDA
GO:0002088 lens development in camera-type eyeIMP
GO:0007155 cell adhesionISO
GO:0007224 smoothened signaling pathwayISO
GO:0007224 smoothened signaling pathwayIGI
GO:0007520 myoblast fusionIMP
GO:0009952 anterior/posterior pattern specificationIMP
GO:0010172 embryonic body morphogenesisIMP
GO:0010172 embryonic body morphogenesisIGI
GO:0014816 skeletal muscle satellite cell differentiationIMP
GO:0016202 regulation of striated muscle tissue developmentISO
GO:0021987 cerebral cortex developmentIMP
GO:0043393 regulation of protein bindingIDA
GO:0043410 positive regulation of MAPK cascadeIMP
GO:0043410 positive regulation of MAPK cascadeIGI
GO:0045663 positive regulation of myoblast differentiationTAS
GO:0045664 regulation of neuron differentiationIMP
GO:0045666 positive regulation of neuron differentiationIDA
GO:0045666 positive regulation of neuron differentiationIMP
GO:0045944 positive regulation of transcription by RNA polymerase IIIGI
GO:0048598 embryonic morphogenesisIGI
GO:0048643 positive regulation of skeletal muscle tissue developmentIMP
GO:0051057 positive regulation of small GTPase mediated signal transductionIMP
GO:0051146 striated muscle cell differentiationIGI
GO:0060059 embryonic retina morphogenesis in camera-type eyeIMP
GO:0098609 cell-cell adhesionTAS
GO:2000179 positive regulation of neural precursor cell proliferationIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005887 integral component of plasma membraneISO
GO:0009986 cell surfaceISO
GO:0009986 cell surfaceTAS

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1266738 Developmental BiologyIEA
R-MMU-162582 Signal TransductionIEA
R-MMU-525793 MyogenesisIEA
R-MMU-5358351 Signaling by HedgehogIEA
R-MMU-5632681 Ligand-receptor interactionsIEA
R-MMU-5632684 Hedgehog 'on' stateIEA
R-MMU-5635838 Activation of SMOIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1003 Cell membrane
KW-1015 Disulfide bond
KW-0325 Glycoprotein
KW-0393 Immunoglobulin domain
KW-0472 Membrane
KW-1185 Reference proteome
KW-0677 Repeat
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR032983 CDO
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

PROSITE

PROSITE ID PROSITE Term
PS50853 FN3
PS50835 IG_LIKE

Pfam

Pfam ID Pfam Term
PF00041 fn3
PF07679 I-set

Protein-protein interaction

Protein-miRNA interaction