| Tag | Content |
|---|---|
| Uniprot ID | Q6DID7; Q8CE42; Q9D2B7; |
| Entrez ID | 68151 |
| Genbank protein ID | BAE34898.1; BAC33950.1; BAB31904.1; AAH75615.1; BAC36788.1; BAC32102.1; AAH18381.1; BAC26300.1; BAC26266.1; |
| Genbank nucleotide ID | XM_006501964.2; NM_026582.4; |
| Ensembl protein ID | ENSMUSP00000143475; ENSMUSP00000067898; |
| Ensembl nucleotide ID | ENSMUSG00000028173 |
| Gene name | Protein wntless homolog |
| Gene symbol | Wls |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E11.5, E12.5, E13.5, E14.5, E15.5, E18.5 |
| Data sources | Manually collected |
| Reference | 21246653; 25922332; 26661618; |
| Functional description | Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development. |
| Sequence | MAGAIIENMS TKKLCIVGGI LLVFQIVAFL VGGLIAPAPT TAVPYTAIKC VDVRKNHHKT 60 RWLAPWGPNK CDKIRDIEEA IPREIEANDI VFSVHIPLPS MEMSPWFQFM LFILQLDIAF 120 KLNNQIRENA EISMDVSLGY RDDMFSEWTE MAHERVPRKL KCTFTSPKTP EHEGRYYNCD 180 VLPFMEIGSV AHKYYLLNIR LPVNEKKKIN VGIGEIKDIR LVGIHQNGGF TKVWFAMKTF 240 LTPSIFIIMV WYWRRITMMS RPPVLLEKVI FALGISMTFI NIPVEWFSIG FDWTWMLLFG 300 DIRQGIFYAM LLSFWIIFCG EHMMDQHERN HIAGYWKQVG PIAVGSFCLF IFDMCERGVQ 360 LTNPFYSIWT TDVGTELAMA FIIVAGICLC LYFLFLCFMV FQVFRNISGK QSSLPAMSKV 420 RRLHYEGLIF RFKFLMLITL ACAAMTVIFF IVSQVSEGHW KWGGVTVQVS SAFFTGIYGM 480 WNLYVFALMF LYAPSHKNYG EDQSNGDLGV HSGEELQLTT TITHVDGPTE IYKLTRKEAQ 540 E 541 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WLS | 528123 | E1BDN1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | WLS | 611491 | E2QUQ5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | WLS | 102174896 | A0A452ES79 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WLS | 100053710 | A0A3Q2HI43 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | WLS | 79971 | Q5T9L3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Wls | 68151 | Q6DID7 | CPO | E11.5, E12.5, E13.5, E14.5, E15.5, E18.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | WLS | 456931 | K7C6F2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WLS | A0A287A5R0 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WLS | 100352518 | G1SDH8 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wls | 362065 | Q6P689 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | wls | 406420 | F2Z4U3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0017147 | Wnt-protein binding | ISO |
| GO:0017147 | Wnt-protein binding | IDA |
| GO:0017147 | Wnt-protein binding | IBA |
| GO:0031852 | mu-type opioid receptor binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001707 | mesoderm formation | IMP |
| GO:0006886 | intracellular protein transport | ISO |
| GO:0006886 | intracellular protein transport | IBA |
| GO:0009948 | anterior/posterior axis specification | IMP |
| GO:0016055 | Wnt signaling pathway | IMP |
| GO:0030177 | positive regulation of Wnt signaling pathway | ISO |
| GO:0030177 | positive regulation of Wnt signaling pathway | ISS |
| GO:0030901 | midbrain development | IMP |
| GO:0030902 | hindbrain development | IMP |
| GO:0031017 | exocrine pancreas development | IMP |
| GO:0061355 | Wnt protein secretion | ISO |
| GO:0061355 | Wnt protein secretion | IBA |
| GO:0061357 | positive regulation of Wnt protein secretion | ISO |
| GO:0061357 | positive regulation of Wnt protein secretion | ISS |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | ISO |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000139 | Golgi membrane | ISO |
| GO:0005769 | early endosome | ISO |
| GO:0005783 | endoplasmic reticulum | ISO |
| GO:0005789 | endoplasmic reticulum membrane | ISO |
| GO:0005794 | Golgi apparatus | ISO |
| GO:0005794 | Golgi apparatus | IDA |
| GO:0005802 | trans-Golgi network | ISO |
| GO:0005829 | cytosol | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0012505 | endomembrane system | IBA |
| GO:0030659 | cytoplasmic vesicle membrane | IEA |
| GO:0031301 | integral component of organelle membrane | IBA |
| GO:0031410 | cytoplasmic vesicle | ISO |
| GO:0031410 | cytoplasmic vesicle | IDA |
| GO:0031901 | early endosome membrane | IEA |
| GO:0032590 | dendrite membrane | ISO |
| GO:0032839 | dendrite cytoplasm | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-3238698 | WNT ligand biogenesis and trafficking | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0025 | Alternative splicing |
| KW-1003 | Cell membrane |
| KW-0968 | Cytoplasmic vesicle |
| KW-0217 | Developmental protein |
| KW-0256 | Endoplasmic reticulum |
| KW-0967 | Endosome |
| KW-0325 | Glycoprotein |
| KW-0333 | Golgi apparatus |
| KW-0472 | Membrane |
| KW-1185 | Reference proteome |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0879 | Wnt signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR009551 | Wntless |