| Tag | Content |
|---|---|
| Uniprot ID | Q6P689 |
| Entrez ID | 362065 |
| Genbank protein ID | AAS75313.1; AAH62391.1; |
| Genbank nucleotide ID | NM_199408.2; NM_001085353.1; |
| Ensembl protein ID | ENSRNOP00000052120 |
| Ensembl nucleotide ID | ENSRNOG00000036816 |
| Gene name | Protein wntless homolog |
| Gene symbol | Wls |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). |
| Sequence | MAGAIIENMS TKKLCIVGGI LLVFQIVAFL VGGLIAPAPT TAVSYVAAKC VDVRKNHHKT 60 RWLMPWGPNK CNKINDFEEA IPREIEANDI VFSVHIPLPS MEMSPWFQFM LFILQIDIAF 120 KLNNQIRENA EVSMDVSLGY RDDMFSEWTE MAHERVPRKL RCTFTSPKTP EHEGRHYECD 180 VLPFMEIGSV AHKYYLLNIR LPVNEKKKIN VGIGEIKDIR LVGIHQNGGF TKVWFAMKTF 240 LTPSIFIIMV WYWRRITMMS RPPVLLEKVI FALGISMTFI NIPVEWFSIG FDWTWMLLFG 300 DIRQGIFYAM LLSFWIIFCG EHMMDQHERN HIAGYWKQVG PIAVGSFCLF IFDMCERGVQ 360 LTNPFYSIWT TDVGTELAMA FIIVAGICLC LYFLFLCFMV FQVFRNISGK QSSLPAMSKV 420 RRLHYEGLIF RFKFLMLITL ACAAMTVIFF IVSQVTEGHW KWGGVTVQVS SAFFTGIYGM 480 WNLYVFALMF LYAPSHKNYG EDQSNGDLGV HSGEELQLTT TITHVDGPTE IYKLTRKEAQ 540 E 541 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WLS | 528123 | E1BDN1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | WLS | 611491 | E2QUQ5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | WLS | 102174896 | A0A452ES79 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WLS | 100053710 | A0A3Q2HI43 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | WLS | 79971 | Q5T9L3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Wls | 68151 | Q6DID7 | CPO | E11.5, E12.5, E13.5, E14.5, E15.5, E18.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | WLS | 456931 | K7C6F2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WLS | A0A287A5R0 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WLS | 100352518 | G1SDH8 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wls | 362065 | Q6P689 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | wls | 406420 | F2Z4U3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031410 | cytoplasmic vesicle |
| GO:0030659 | cytoplasmic vesicle membrane |
| GO:0005829 | cytosol |
| GO:0032839 | dendrite cytoplasm |
| GO:0032590 | dendrite membrane |
| GO:0005769 | early endosome |
| GO:0031901 | early endosome membrane |
| GO:0012505 | endomembrane system |
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0005794 | Golgi apparatus |
| GO:0000139 | Golgi membrane |
| GO:0031301 | integral component of organelle membrane |
| GO:0005886 | plasma membrane |
| GO:0005802 | trans-Golgi network |
| GO:0031852 | mu-type opioid receptor binding |
| GO:0017147 | Wnt-protein binding |
| GO:0009948 | anterior/posterior axis specification |
| GO:0031017 | exocrine pancreas development |
| GO:0030902 | hindbrain development |
| GO:0006886 | intracellular protein transport |
| GO:0001707 | mesoderm formation |
| GO:0030901 | midbrain development |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0061357 | positive regulation of Wnt protein secretion |
| GO:0030177 | positive regulation of Wnt signaling pathway |
| GO:0061355 | Wnt protein secretion |
| GO:0016055 | Wnt signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-0968 | Cytoplasmic vesicle |
| KW-0217 | Developmental protein |
| KW-0256 | Endoplasmic reticulum |
| KW-0967 | Endosome |
| KW-0325 | Glycoprotein |
| KW-0333 | Golgi apparatus |
| KW-0472 | Membrane |
| KW-1185 | Reference proteome |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0879 | Wnt signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR009551 | Wntless |