1. Differentially methylated genes

We reviewed >300 publications obtained by searching in PubMed using the keywords "schizophrenia and mythylation". The studies listed below are all "genome-wide". Among them, data from five studies are available and are deposited in SZGR2.

Study ID Platform # CpGs Description DMG Tissue In SZGR2
DMG:Montano_2016 Illumina HumanMethylation450 BeadChip 456,513 CpG 689 schizophrenia and 645 controls 172 records Included
DMG:Wockner_2014 Illumina HumanMethylation450 BeadChip 485,000 CpG 24 schizophrenia and 24 controls 4641 Blood Included
DMG:Nishioka_2013 Illumina Infinium HumanMethylation27 BeadChip 27,578 CpG 18 Japanese FESZ patients (11 males and 7 females); 15 Japanese age-matched healthy controls (10 males and 5 females) 603 Blood Included
DMG:Jaffe_2016 Illumina HumanMethylation450 BeadChip 485,000 CpG 108 schizophrenia and 136 controls 2104 DLPFC Included
DMG:vanEijk_2014 525 Blood Included
Aberg 2014 MBD-seq 26,752,702 autosomal CpG sites Discovery: 178 SZ and 182 control;
Replication: 561 SZ and 582 control		 139 tests at q<0.01 Blood Data not available
Chen 2014 Illumina Infinium HumanMethylation27 BeadChips 20,769 CpG 118 samples with both expression arrays and 138 methylation arrays; including 39 schizophrenia, 36 bipolar disorder, and 43 controls Brain cerebellar tissues Data not available

2. Brain methylation QTL (meQTL) data

We collected 3 sets of meQTL data

Study ID Platform # CpGs Description DMG Tissue In SZGR2
DMG:Jaffe_2016 Illumina HumanMethylation450 BeadChip 485,000 CpG 258 (age>13) 4,107,214 significant SNP-CpG methylation associations (meQTLs) at FDR < 1% DLPFC Included
DMG:vanEijk_2014 1447 Blood Included
Hannon 2016 26,752,702 autosomal CpG sites Discovery: 178 SZ and 182 control;
Replication: 561 SZ and 582 control		 658492 records brain Data not available