SNPs of Tier 1 set were collected from five independent resources: GWAS Catalog (CV:GWAScat), GWASdb, PheWAS, PGC2, and a multi-stage GWA study. These SNPs have strong evidence for their association with schizophrenia, reaching genome-wide significance in most cases. Raw records were remapped to the human reference genome hg19 if necessary. SNPs were then annotated systematically using the tool wANNOVAR. Raw records were displayed in the SNP page and the gene page in the same way as they were originally obtained.

SNPs of Tier 2 set were collected from the PGC2 summary results, with a nominal p-value <0.05. Tier 2 SNPs are searchable but not listed in the browse page because the number is too large.

Venn diagram comparing the SNPs among the five Tier 1 SNPs.

Not available

Venn diagram comparing the genes mapped to Tier 1 SNPs within 50kb.

Not available

Study ID # genes with non-silent mutations # genes with only intronic or silent mutations
DNM:Awadalla_2010 13 2
DNM:Fromer_2014 503 137
DNM:Girard_2011 15 0
DNM:Guipponi_2014 49 0
DNM:Kranz_2015 4 1
DNM:McCarthy_2014 66 0
DNM:Xu_2012 150 32
Locus Studies References Replication # genes
1q21.1 del CNV:Levinson_2011 21285140 Yes 35
CNV:Rees_2014 24311552
2p16.3 CNV:Levinson_2011 21285140 Yes 1
CNV:Rees_2014 24311552
3q29 CNV:Levinson_2011 21285140 Yes 21
CNV:Rees_2014 24311552
7q11.23 CNV:Sanders_2011 21658581 Yes 26
CNV:Rees_2014 24311552
7q36.3 CNV:Levinson_2011 21285140 Yes 1
CNV:Rees_2014 24311552
15q11.2 CNV:Rees_2014 24311552 No 14
AS/PWS dup CNV:Rees_2014 24311552 No 1
15q13.3 del CNV:Levinson_2011 21285140 Yes 16
CNV:Rees_2014 24311552
16p13.11 dup CNV:Rees_2014 21285140 No 9
16p11.2 dup CNV:Levinson_2011 21285140 Yes 27
CNV:Rees_2014 24311552
17q12 del CNV:Levinson_2011 192 Yes 17
CNV:Rees_2014 24311552
22q11.21 del CNV:Levinson_2011 192 Yes 49
CNV:Rees_2014 24311552