Gene Page: SLC17A4
Summary ?
| GeneID | 10050 |
| Symbol | SLC17A4 |
| Synonyms | KAIA2138 |
| Description | solute carrier family 17 member 4 |
| Reference | MIM:604216|HGNC:HGNC:10932|Ensembl:ENSG00000146039|HPRD:05022|Vega:OTTHUMG00000014410 |
| Gene type | protein-coding |
| Map location | 6p22.2 |
| Pascal p-value | 2.195E-7 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16869851 | chr4 | 20690056 | SLC17A4 | 10050 | 0.03 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C1orf124 | 0.78 | 0.74 |
| SLC35F5 | 0.78 | 0.76 |
| PTCD3 | 0.77 | 0.71 |
| ARFIP1 | 0.77 | 0.73 |
| AC012100.1 | 0.76 | 0.77 |
| C5orf33 | 0.76 | 0.73 |
| PGM3 | 0.76 | 0.74 |
| DARS | 0.76 | 0.70 |
| ERLIN2 | 0.76 | 0.71 |
| NARG2 | 0.76 | 0.76 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.57 | -0.52 |
| MT-CO2 | -0.55 | -0.53 |
| AF347015.27 | -0.51 | -0.51 |
| AF347015.8 | -0.51 | -0.51 |
| AF347015.31 | -0.50 | -0.52 |
| MT-CYB | -0.50 | -0.50 |
| AF347015.33 | -0.49 | -0.49 |
| IL32 | -0.49 | -0.41 |
| IFI27 | -0.49 | -0.48 |
| HIGD1B | -0.46 | -0.45 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005436 | sodium:phosphate symporter activity | TAS | 10319585 | |
| GO:0005215 | transporter activity | IEA | - | |
| GO:0015293 | symporter activity | IEA | - | |
| GO:0031402 | sodium ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006814 | sodium ion transport | TAS | 10319585 | |
| GO:0006811 | ion transport | IEA | - | |
| GO:0006796 | phosphate metabolic process | TAS | 10319585 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005624 | membrane fraction | TAS | 10319585 | |
| GO:0016020 | membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 10319585 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| WANG CLIM2 TARGETS UP | 269 | 146 | All SZGR 2.0 genes in this pathway |
| SABATES COLORECTAL ADENOMA DN | 291 | 176 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D UP | 210 | 124 | All SZGR 2.0 genes in this pathway |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP | 174 | 96 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |