Gene Page: HHLA1
Summary ?
GeneID | 10086 |
Symbol | HHLA1 |
Synonyms | PLA2L |
Description | HERV-H LTR-associating 1 |
Reference | MIM:604109|HGNC:HGNC:4904|Ensembl:ENSG00000132297|HPRD:06823| |
Gene type | protein-coding |
Map location | 8q24 |
Pascal p-value | 0.031 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
BHLHE41 | 0.61 | 0.61 |
TCFL5 | 0.61 | 0.52 |
CBR1 | 0.58 | 0.62 |
APOD | 0.58 | 0.61 |
CD74 | 0.56 | 0.63 |
IL17D | 0.56 | 0.55 |
CEBPB | 0.56 | 0.54 |
HSPB8 | 0.56 | 0.63 |
HLA-DRB1 | 0.56 | 0.59 |
CYS1 | 0.55 | 0.53 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
NKIRAS2 | -0.40 | -0.41 |
TUBB2B | -0.39 | -0.47 |
ZBTB8A | -0.39 | -0.38 |
YBX1 | -0.39 | -0.46 |
KIAA1949 | -0.39 | -0.41 |
IGF2BP3 | -0.39 | -0.48 |
IDH1 | -0.38 | -0.44 |
ZNF286 | -0.38 | -0.38 |
FNBP1L | -0.38 | -0.38 |
HMGB3 | -0.38 | -0.41 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
BROCKE APOPTOSIS REVERSED BY IL6 | 144 | 98 | All SZGR 2.0 genes in this pathway |
CHEOK RESPONSE TO HD MTX UP | 23 | 13 | All SZGR 2.0 genes in this pathway |
ASTIER INTEGRIN SIGNALING | 59 | 44 | All SZGR 2.0 genes in this pathway |
KIM GASTRIC CANCER CHEMOSENSITIVITY | 103 | 64 | All SZGR 2.0 genes in this pathway |
CROMER TUMORIGENESIS UP | 63 | 36 | All SZGR 2.0 genes in this pathway |