Summary ?
GeneID10086
SymbolHHLA1
SynonymsPLA2L
DescriptionHERV-H LTR-associating 1
ReferenceMIM:604109|HGNC:HGNC:4904|Ensembl:ENSG00000132297|HPRD:06823|
Gene typeprotein-coding
Map location8q24
Pascal p-value0.031

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BHLHE410.610.61
TCFL50.610.52
CBR10.580.62
APOD0.580.61
CD740.560.63
IL17D0.560.55
CEBPB0.560.54
HSPB80.560.63
HLA-DRB10.560.59
CYS10.550.53
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NKIRAS2-0.40-0.41
TUBB2B-0.39-0.47
ZBTB8A-0.39-0.38
YBX1-0.39-0.46
KIAA1949-0.39-0.41
IGF2BP3-0.39-0.48
IDH1-0.38-0.44
ZNF286-0.38-0.38
FNBP1L-0.38-0.38
HMGB3-0.38-0.41

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BROCKE APOPTOSIS REVERSED BY IL6 14498All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO HD MTX UP 2313All SZGR 2.0 genes in this pathway
ASTIER INTEGRIN SIGNALING 5944All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 10364All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS UP 6336All SZGR 2.0 genes in this pathway