Gene Page: ACTR2

Summary
GeneID  10097
Symbol  ACTR2
Synonyms  ARP2
Description  ARP2 actin-related protein 2 homolog (yeast)
See related  HGNC:169|MIM:604221|Ensembl:ENSG00000138071|HPRD:05023|
Locus tag  -
Gene type  protein-coding
Map location  2p14
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EIF4ENIF10.900.88
AC020663.10.900.88
C1orf1630.900.92
PDXDC10.890.89
RABGEF10.890.88
HEATR5B0.890.91
NHEDC20.890.87
ALS20.890.91
BAI30.890.88
MSL10.890.88
Top 10 negatively co-expressed genes
MT-CO2-0.84-0.83
AF347015.31-0.83-0.84
AF347015.21-0.81-0.84
AF347015.33-0.80-0.81
FXYD1-0.80-0.81
AF347015.8-0.80-0.82
AF347015.27-0.80-0.82
MT-CYB-0.79-0.80
HIGD1B-0.79-0.81
AF347015.2-0.77-0.80
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003779actin bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006928cell motionTAS9230079 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0005737cytoplasmIEA-
GO:0005885Arp2/3 protein complexTAS9230079 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTC1ACTC | CMD1R | CMH11actin, alpha, cardiac muscle 1-HPRD,BioGRID12019562 
ACTR3ARP3ARP3 actin-related protein 3 homolog (yeast)Co-purificationBioGRID11741539 
Arp2/3 complex subunits Arp2 and Arp3 interactBIND11721045 |11741539 
ACTR3BARP11 | ARP3BETA | DKFZp686O24114ARP3 actin-related protein 3 homolog B (yeast)Affinity Capture-MSBioGRID17353931 
ARPC1BARC41 | p40-ARC | p41-ARCactin related protein 2/3 complex, subunit 1B, 41kDa-HPRD9230079 |11721045 
Arp2/3 complex subunits p41 and Arp2 interactBIND11741539 
ARPC2ARC34 | PNAS-139 | PRO2446 | p34-Arcactin related protein 2/3 complex, subunit 2, 34kDa-HPRD9230079 
ARPC3ARC21 | p21-Arcactin related protein 2/3 complex, subunit 3, 21kDa-HPRD9000076 
ARPC4ARC20 | MGC13544 | p20-Arcactin related protein 2/3 complex, subunit 4, 20kDaArp2/3 complex subunits p20 and Arp2 interactBIND11721045 |11741539 
-HPRD11162547 
ARPC5ARC16 | MGC88523 | dJ127C7.3 | p16-Arcactin related protein 2/3 complex, subunit 5, 16kDaArp2/3 complex subunits p16 and Arp2 interactBIND11741539 
BAK1BAK | BAK-LIKE | BCL2L7 | CDN1 | MGC117255 | MGC3887BCL2-antagonist/killer 1Affinity Capture-MSBioGRID17353931 
BMP2BMP2Abone morphogenetic protein 2Reconstituted ComplexBioGRID10880444 
CTTNEMS1 | FLJ34459cortactinAffinity Capture-MSBioGRID11018051 
HCLS1CTTNL | HS1hematopoietic cell-specific Lyn substrate 1-HPRD12534372 
IQGAP2-IQ motif containing GTPase activating protein 2-HPRD12515716 
WASF2SCAR2 | WAVE2 | dJ393P12.2WAS protein family, member 2-HPRD9889097 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_SALMONELLA_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY 3428All SZGR genes in this pathway
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
BIOCARTA_CDC42RAC_PATHWAY 1613All SZGR genes in this pathway
BIOCARTA_ACTINY_PATHWAY 2014All SZGR genes in this pathway
SIG_CHEMOTAXIS 4537All SZGR genes in this pathway
SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 3525All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN 352225All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN 275168All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_DN 8659All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP 6446All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
YANAGIHARA_ESX1_TARGETS 3019All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
WOOD_EBV_EBNA1_TARGETS_DN 4733All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
FALVELLA_SMOKERS_WITH_LUNG_CANCER 8052All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_8WK 4738All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
CHENG_RESPONSE_TO_NICKEL_ACETATE 4529All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
SPIRA_SMOKERS_LUNG_CANCER_UP 3824All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_UP 6242All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_UP 7349All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP 9159All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98165016561Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-15/16/195/424/497235241m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-24*255261m8hsa-miR-189GUGCCUACUGAGCUGAUAUCAGU
miR-338168116881A,m8hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-5033093151Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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