Gene Page: SF3A1

Summary
GeneID  10291
Symbol  SF3A1
Synonyms  PRP21|PRPF21|SAP114|SF3A120
Description  splicing factor 3a, subunit 1, 120kDa
See related  HGNC:10765|MIM:605595|Ensembl:ENSG00000099995|HPRD:06903|
Locus tag  -
Gene type  protein-coding
Map location  22q12.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TCEAL70.780.85
CALM20.760.84
UBE2B0.740.75
GLRX20.740.77
NKIRAS10.730.81
MOCS20.720.76
COMMD80.720.79
KRT222P0.720.73
NDUFAF40.710.80
FBXO90.710.76
Top 10 negatively co-expressed genes
HIF3A-0.47-0.54
AC020763.2-0.45-0.49
CDC42EP4-0.44-0.50
SEMA4B-0.43-0.47
FAM59B-0.43-0.48
RP4-697K14.1-0.43-0.53
SMTN-0.43-0.51
EPHA2-0.42-0.50
MTSS1L-0.39-0.44
NFKB2-0.39-0.45
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003723RNA bindingIDA10882114 
GO:0003723RNA bindingIEA-
GO:0005515protein bindingIPI10976766 |17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000389nuclear mRNA 3'-splice site recognitionTAS15647371 
GO:0000398nuclear mRNA splicing, via spliceosomeEXP12226669 
GO:0000398nuclear mRNA splicing, via spliceosomeIDA10882114 
GO:0006396RNA processingIEA-
GO:0008380RNA splicingIEA-
GO:0006464protein modification processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005684U2-dependent spliceosomeIDA10882114 
GO:0005730nucleolusIDA18029348 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATG12APG12 | APG12L | FBR93 | HAPG12ATG12 autophagy related 12 homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1Co-purificationBioGRID11013263 
SF3A2PRP11 | PRPF11 | SAP62 | SF3a66splicing factor 3a, subunit 2, 66kDaSF3a66 interacts with SF3a120.BIND11533230 
Affinity Capture-MSBioGRID12234937 
SF3A3PRP9 | PRPF9 | SAP61 | SF3a60splicing factor 3a, subunit 3, 60kDaSF3a60 interacts with SF3a120.BIND11533230 
-HPRD,BioGRID8022796 |11533230 
SP1-Sp1 transcription factor-HPRD10976766 
TCERG1CA150 | MGC133200 | TAF2Stranscription elongation regulator 1-HPRD,BioGRID15456888 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_SPLICEOSOME 12872All SZGR genes in this pathway
REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 14077All SZGR genes in this pathway
REACTOME_MRNA_PROCESSING 16186All SZGR genes in this pathway
REACTOME_MRNA_SPLICING 11158All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
WANG_CLIM2_TARGETS_DN 186114All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN 187122All SZGR genes in this pathway
LIN_APC_TARGETS 7755All SZGR genes in this pathway
DER_IFN_GAMMA_RESPONSE_UP 7145All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP 11371All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN 238145All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
THILLAINADESAN_ZNF217_TARGETS_UP 4422All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway


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