Summary ?
Descriptionnucleophosmin/nucleoplasmin 2
Gene typeprotein-coding
Map location8p21.3
Pascal p-value0.76
Sherlock p-value0.882
Fetal beta-0.836
DMG1 (# studies)
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_IGenome scan meta-analysisPsr: 0.031 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.03086 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003676nucleic acid bindingIEA-
GO:0042393histone bindingTAS12581654 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006338chromatin remodelingIDA12714744 
GO:0007338single fertilizationIMP12714744 
GO:0007096regulation of exit from mitosisIMP12714744 
GO:0009790embryonic developmentIMP12714744 
GO:0009994oocyte differentiationIEP12714744 
GO:0045836positive regulation of meiosisIMP12714744 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000789cytoplasmic chromatinIDA12714744 
GO:0000790nuclear chromatinIDA12714744 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261155All SZGR 2.0 genes in this pathway
GAZIN EPIGENETIC SILENCING BY KRAS 2616All SZGR 2.0 genes in this pathway
MATZUK MATERNAL EFFECT 98All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway