Gene Page: ERN2

Summary ?
GeneID10595
SymbolERN2
SynonymsIRE1-BETA|IRE1b|IRE2p|hIRE2p
Descriptionendoplasmic reticulum to nucleus signaling 2
ReferenceMIM:604034|HGNC:HGNC:16942|Ensembl:ENSG00000134398|HPRD:04944|Vega:OTTHUMG00000177020
Gene typeprotein-coding
Map location16p12.2
Pascal p-value0.243
Fetal beta-0.119
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg051314831623706242ERN24.503E-4-0.3520.045DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ENOSF10.610.53
CHD1L0.610.58
BEST10.590.53
KIAA17550.580.58
CDC14B0.580.56
CYTSB0.580.57
CA140.570.56
IGSF110.570.52
FAM63A0.560.51
LITAF0.560.53
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C1orf86-0.40-0.44
EMID1-0.38-0.42
AC011491.1-0.35-0.39
RPRM-0.34-0.38
RASGEF1C-0.34-0.32
CD1D-0.34-0.36
COMTD1-0.34-0.37
GPRIN1-0.33-0.32
SLC1A6-0.33-0.38
LRFN4-0.33-0.35

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIDA11175748 
GO:0005524ATP bindingIDA11175748 
GO:0004519endonuclease activityIDA11175748 
GO:0004674protein serine/threonine kinase activityIDA11175748 
GO:0016787hydrolase activityIEA-
GO:0016740transferase activityIEA-
GO:0016891endoribonuclease activity, producing 5'-phosphomonoestersIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006397mRNA processingIEA-
GO:0006468protein amino acid phosphorylationIDA11175748 
GO:0016075rRNA catabolic processIDA11175748 
GO:0006917induction of apoptosisIMP11175748 
GO:0006950response to stressIEA-
GO:0007050cell cycle arrestIEA-
GO:0006915apoptosisIEA-
GO:0016481negative regulation of transcriptionIMP11175748 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M 216124All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway