Gene Page: ERN2

Summary
GeneID  10595
Symbol  ERN2
Synonyms  IRE1b
Description  endoplasmic reticulum to nucleus signaling 2
See related  HGNC:16942|MIM:604034|Ensembl:ENSG00000134398|HPRD:04944|
Locus tag  -
Gene type  protein-coding
Map location  16p12.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ENOSF10.610.53
CHD1L0.610.58
BEST10.590.53
KIAA17550.580.58
CDC14B0.580.56
CYTSB0.580.57
CA140.570.56
IGSF110.570.52
FAM63A0.560.51
LITAF0.560.53
Top 10 negatively co-expressed genes
C1orf86-0.40-0.44
EMID1-0.38-0.42
AC011491.1-0.35-0.39
RPRM-0.34-0.38
RASGEF1C-0.34-0.32
CD1D-0.34-0.36
COMTD1-0.34-0.37
GPRIN1-0.33-0.32
SLC1A6-0.33-0.38
LRFN4-0.33-0.35
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIDA11175748 
GO:0005524ATP bindingIDA11175748 
GO:0004519endonuclease activityIDA11175748 
GO:0004674protein serine/threonine kinase activityIDA11175748 
GO:0016787hydrolase activityIEA-
GO:0016740transferase activityIEA-
GO:0016891endoribonuclease activity, producing 5'-phosphomonoestersIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006397mRNA processingIEA-
GO:0006468protein amino acid phosphorylationIDA11175748 
GO:0016075rRNA catabolic processIDA11175748 
GO:0006917induction of apoptosisIMP11175748 
GO:0006950response to stressIEA-
GO:0007050cell cycle arrestIEA-
GO:0006915apoptosisIEA-
GO:0016481negative regulation of transcriptionIMP11175748 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
 
Pathway annotation


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