Gene Page: AP2M1

Summary ?
GeneID1173
SymbolAP2M1
SynonymsAP50|CLAPM1|mu2
Descriptionadaptor related protein complex 2 mu 1 subunit
ReferenceMIM:601024|HGNC:HGNC:564|Ensembl:ENSG00000161203|HPRD:03014|Vega:OTTHUMG00000156822
Gene typeprotein-coding
Map location3q28
Pascal p-value0.301
Sherlock p-value0.826
Fetal beta-0.87
DMG2 (# studies)
SupportENDOCYTOSIS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Montano_2016Genome-wide DNA methylation analysisThis dataset includes 172 replicated associations between CpGs with schizophrenia. 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg173434513183899704AP2M13.2E-40.0060.184DMG:Montano_2016
cg236790853183892773AP2M17.35E-9-0.0083.66E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TM9SF30.950.95
FBXW110.920.91
ZDHHC170.920.92
LONP20.910.90
PDZD80.910.91
HIPK30.910.92
GARNL10.900.91
APPL10.900.92
FAM91A10.900.92
SERINC10.900.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.65-0.55
FXYD1-0.62-0.55
C1orf54-0.61-0.58
MT-CO2-0.61-0.56
HIGD1B-0.60-0.55
ENHO-0.60-0.60
IL32-0.60-0.52
VAMP5-0.59-0.49
CSAG1-0.59-0.53
C1orf61-0.58-0.63

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRA1BADRA1 | ALPHA1BARadrenergic, alpha-1B-, receptorAffinity Capture-Western
Two-hybrid		BioGRID12644451 
AP2B1ADTB2 | AP105B | AP2-BETA | CLAPB1 | DKFZp781K0743adaptor-related protein complex 2, beta 1 subunitTwo-hybridBioGRID16189514 
AQP4HMIWC2 | MGC22454 | MIWCaquaporin 4-HPRD,BioGRID11742978 
CD22FLJ22814 | MGC130020 | SIGLEC-2 | SIGLEC2CD22 molecule-HPRD,BioGRID12646615 
CLEC4MCD209L | CD299 | DC-SIGN2 | DC-SIGNR | DCSIGNR | HP10347 | L-SIGN | LSIGN | MGC129964 | MGC47866C-type lectin domain family 4, member MAffinity Capture-WesternBioGRID12621057 
CTLA4CD152 | CELIAC3 | CTLA-4 | GSE | IDDM12cytotoxic T-lymphocyte-associated protein 4Affinity Capture-Western
Co-crystal Structure
Reconstituted Complex
Two-hybrid		BioGRID9200449 |11583591 
CTLA4CD152 | CELIAC3 | CTLA-4 | GSE | IDDM12cytotoxic T-lymphocyte-associated protein 4-HPRD9200449 |9256472 
|11583591|9256472 
DAB2DOC-2 | DOC2 | FLJ26626disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)-HPRD11247302 
DCXDBCN | DC | LISX | SCLH | XLISdoublecortin-HPRD11591131 
DPPA2PESCRG1developmental pluripotency associated 2Two-hybridBioGRID16189514 
DVL2-dishevelled, dsh homolog 2 (Drosophila)Two-hybridBioGRID16189514 
EHD2FLJ96617 | PAST2EH-domain containing 2-HPRD,BioGRID15182197 
FURINFUR | PACE | PCSK3 | SPC1furin (paired basic amino acid cleaving enzyme)-HPRD,BioGRID10593987 
FXR2FMR1L2fragile X mental retardation, autosomal homolog 2Two-hybridBioGRID16189514 
IKZF1Hs.54452 | IK1 | IKAROS | LYF1 | PRO0758 | ZNFN1A1 | hIk-1IKAROS family zinc finger 1 (Ikaros)Two-hybridBioGRID16189514 
L1CAMCAML1 | CD171 | HSAS | HSAS1 | MASA | MIC5 | N-CAML1 | S10 | SPG1L1 cell adhesion moleculeL1CAM interacts with AP-2 mu2 chain. This interaction was modelled on a demonstrated interaction between human L1CAM and AP-2 mu2 chain from an unspecified species.BIND15647482 
LAMP1CD107a | LAMPA | LGP120lysosomal-associated membrane protein 1-HPRD,BioGRID7569928 
LY9CD229 | SLAMF3 | hly9 | mLY9lymphocyte antigen 9-HPRD,BioGRID12621057 
MED4DRIP36 | FLJ10956 | HSPC126 | RP11-90M2.2 | TRAP36 | VDRIPmediator complex subunit 4Two-hybridBioGRID16189514 
MEGF10DKFZp781K1852 | FLJ41574 | KIAA1780multiple EGF-like-domains 10-HPRD12421765 
RALBP1RIP1 | RLIP1 | RLIP76ralA binding protein 1RLIP76 interacts with mu-2.BIND10910768 
RTDR1MGC16968rhabdoid tumor deletion region gene 1Two-hybridBioGRID16189514 
RUNDC3ARAP2IP | RPIP8RUN domain containing 3ATwo-hybridBioGRID16189514 
STON2STN2 | STNB | STNB2stonin 2Reconstituted ComplexBioGRID11454741 
TBC1D5KIAA0210TBC1 domain family, member 5Two-hybridBioGRID16189514 
TGOLN2MGC14722 | TGN38 | TGN46 | TGN48 | TGN51 | TTGN2trans-golgi network protein 2TGN38 interacts with Mu2. This interaction was modeled on a demonstrated interaction between TGN38 from unspecified species and rat Mu2.BIND15916959 
ZBTB8BOZF1 | FLJ90065 | MGC17919zinc finger and BTB domain containing 8Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185109All SZGR 2.0 genes in this pathway
BIOCARTA NDKDYNAMIN PATHWAY 2115All SZGR 2.0 genes in this pathway
BIOCARTA PTDINS PATHWAY 2316All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN PATHWAY 108All SZGR 2.0 genes in this pathway
PID ARF 3PATHWAY 1913All SZGR 2.0 genes in this pathway
REACTOME GAP JUNCTION DEGRADATION 108All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING 12974All SZGR 2.0 genes in this pathway
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 2112All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER 10980All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137105All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION 9161All SZGR 2.0 genes in this pathway
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING 137All SZGR 2.0 genes in this pathway
REACTOME EGFR DOWNREGULATION 2514All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137110All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251188All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS 2823All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 1611All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS 8662All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1 3425All SZGR 2.0 genes in this pathway
REACTOME RECYCLING PATHWAY OF L1 2715All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 2819All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME GAP JUNCTION TRAFFICKING 2719All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP 11271All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP 11268All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 14789All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408274All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS DN 4031All SZGR 2.0 genes in this pathway
RAMPON ENRICHED LEARNING ENVIRONMENT EARLY UP 1512All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX DN 5443All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211119All SZGR 2.0 genes in this pathway