Gene Page: WDR64
Summary ?
| GeneID | 128025 |
| Symbol | WDR64 |
| Synonyms | - |
| Description | WD repeat domain 64 |
| Reference | HGNC:HGNC:26570|Ensembl:ENSG00000162843|HPRD:13412| |
| Gene type | protein-coding |
| Map location | 1q43 |
| Fetal beta | 0.109 |
| eGene | Anterior cingulate cortex BA24 Cortex Frontal Cortex BA9 Myers' cis & trans |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| WDR64 | chr1 | 241850816 | C | T | NM_144625 | p.288A>V | missense | Schizophrenia | DNM:Fromer_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs149319 | chr5 | 96025248 | WDR64 | 128025 | 0.17 | trans | ||
| rs6429292 | 1 | 241850498 | WDR64 | ENSG00000162843.13 | 1.18592E-6 | 0.03 | 34918 | gtex_brain_ba24 |
| rs12133073 | 1 | 241851745 | WDR64 | ENSG00000162843.13 | 8.27615E-7 | 0.03 | 36165 | gtex_brain_ba24 |
| rs60280115 | 1 | 241852608 | WDR64 | ENSG00000162843.13 | 1.61028E-6 | 0.03 | 37028 | gtex_brain_ba24 |
| rs7543214 | 1 | 241853330 | WDR64 | ENSG00000162843.13 | 8.631E-7 | 0.03 | 37750 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ACEVEDO LIVER CANCER WITH H3K27ME3 UP | 295 | 149 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K9ME3 UP | 141 | 75 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |