Gene Page: ARHGEF19
Summary ?
| GeneID | 128272 |
| Symbol | ARHGEF19 |
| Synonyms | WGEF |
| Description | Rho guanine nucleotide exchange factor 19 |
| Reference | MIM:612496|HGNC:HGNC:26604|Ensembl:ENSG00000142632|HPRD:10659|Vega:OTTHUMG00000002219 |
| Gene type | protein-coding |
| Map location | 1p36.13 |
| Pascal p-value | 0.047 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs221035 | 1 | 16526529 | ARHGEF19 | ENSG00000142632.12 | 1.49994E-8 | 0 | 12575 | gtex_brain_putamen_basal |
| rs200243292 | 1 | 16528472 | ARHGEF19 | ENSG00000142632.12 | 2.13619E-9 | 0 | 10632 | gtex_brain_putamen_basal |
| rs221045 | 1 | 16530049 | ARHGEF19 | ENSG00000142632.12 | 9.28062E-9 | 0 | 9055 | gtex_brain_putamen_basal |
| rs221052 | 1 | 16533022 | ARHGEF19 | ENSG00000142632.12 | 8.85589E-9 | 0 | 6082 | gtex_brain_putamen_basal |
| rs71574166 | 1 | 16533830 | ARHGEF19 | ENSG00000142632.12 | 1.56673E-8 | 0 | 5274 | gtex_brain_putamen_basal |
| rs221061 | 1 | 16535804 | ARHGEF19 | ENSG00000142632.12 | 3.41965E-8 | 0 | 3300 | gtex_brain_putamen_basal |
| rs221063 | 1 | 16537289 | ARHGEF19 | ENSG00000142632.12 | 3.42836E-8 | 0 | 1815 | gtex_brain_putamen_basal |
| rs3030196 | 1 | 16537781 | ARHGEF19 | ENSG00000142632.12 | 6.85314E-8 | 0 | 1323 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA MYOSIN PATHWAY | 31 | 22 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PAR1 PATHWAY | 37 | 28 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES LCP WITH H3K4ME3 | 142 | 80 | All SZGR 2.0 genes in this pathway |
| DELACROIX RARG BOUND MEF | 367 | 231 | All SZGR 2.0 genes in this pathway |