Gene Page: CPN1
Summary ?
GeneID | 1369 |
Symbol | CPN1 |
Synonyms | CPN|SCPN |
Description | carboxypeptidase N subunit 1 |
Reference | MIM:603103|HGNC:HGNC:2312|Ensembl:ENSG00000120054|HPRD:09120|Vega:OTTHUMG00000018896 |
Gene type | protein-coding |
Map location | 10q24.2 |
Pascal p-value | 0.73 |
DMG | 1 (# studies) |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg15457079 | 10 | 101841816 | CPN1 | 3.326E-4 | -0.478 | 0.041 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
SELL | 0.46 | 0.37 |
HAVCR2 | 0.44 | 0.44 |
LIPA | 0.42 | 0.45 |
FECH | 0.42 | 0.49 |
C3AR1 | 0.42 | 0.44 |
TMEM64 | 0.42 | 0.43 |
EVI2B | 0.42 | 0.37 |
EDIL3 | 0.41 | 0.45 |
MAN1A1 | 0.41 | 0.41 |
RHOU | 0.40 | 0.40 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
RP9P | -0.23 | -0.27 |
IL32 | -0.22 | -0.17 |
AF347015.18 | -0.22 | -0.23 |
NSBP1 | -0.22 | -0.24 |
AC098691.2 | -0.21 | -0.23 |
AC005921.3 | -0.21 | -0.23 |
AC010300.1 | -0.21 | -0.29 |
AL022328.1 | -0.21 | -0.17 |
AC007216.4 | -0.20 | -0.16 |
AC022692.2 | -0.20 | -0.20 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
ONKEN UVEAL MELANOMA DN | 526 | 357 | All SZGR 2.0 genes in this pathway |
PASQUALUCCI LYMPHOMA BY GC STAGE DN | 165 | 104 | All SZGR 2.0 genes in this pathway |
SHEPARD BMYB MORPHOLINO UP | 205 | 126 | All SZGR 2.0 genes in this pathway |
SANSOM APC TARGETS UP | 126 | 84 | All SZGR 2.0 genes in this pathway |
RAMASWAMY METASTASIS DN | 61 | 47 | All SZGR 2.0 genes in this pathway |
SU LIVER | 55 | 32 | All SZGR 2.0 genes in this pathway |
ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
BOYLAN MULTIPLE MYELOMA D UP | 89 | 62 | All SZGR 2.0 genes in this pathway |
COULOUARN TEMPORAL TGFB1 SIGNATURE DN | 138 | 99 | All SZGR 2.0 genes in this pathway |
HOSHIDA LIVER CANCER SURVIVAL DN | 113 | 76 | All SZGR 2.0 genes in this pathway |
MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
KAMMINGA SENESCENCE | 41 | 26 | All SZGR 2.0 genes in this pathway |
SERVITJA ISLET HNF1A TARGETS DN | 109 | 71 | All SZGR 2.0 genes in this pathway |
ALFANO MYC TARGETS | 239 | 156 | All SZGR 2.0 genes in this pathway |
FOSTER KDM1A TARGETS UP | 266 | 142 | All SZGR 2.0 genes in this pathway |