Gene Page: CRYAA

Summary ?
GeneID1409
SymbolCRYAA
SynonymsCRYA1|CTRCT9|HSPB4
Descriptioncrystallin alpha A
ReferenceMIM:123580|HGNC:HGNC:2388|Ensembl:ENSG00000160202|HPRD:00427|Vega:OTTHUMG00000086842
Gene typeprotein-coding
Map location21q22.3
Pascal p-value0.038
Fetal beta-0.695

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C16orf790.440.33
NSUN5C0.410.35
AL022328.10.410.33
NSUN5B0.400.32
AC011511.10.400.32
NEIL10.400.34
GSDMB0.380.33
FGF170.380.26
ZNF6920.380.29
CCDC840.370.29
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KLHL5-0.30-0.29
ARHGAP5-0.30-0.27
NET1-0.30-0.26
TMED7-0.30-0.27
PDE3A-0.30-0.28
ABCD2-0.29-0.25
TNFRSF1B-0.29-0.24
TICAM2-0.29-0.26
TBC1D12-0.29-0.27
VWF-0.29-0.24

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ALBDKFZp779N1935 | PRO0883 | PRO0903 | PRO1341albumin-HPRD9618718 
BAXBCL2L4BCL2-associated X proteinHalphaA-crystallin interacts with Bax.BIND14752512 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1HalphaA-crystallin interacts with Bcl-Xs.BIND14752512 
CRYAACRYA1 | HSPB4crystallin, alpha ATwo-hybridBioGRID11700327 
CRYABCRYA2 | CTPP2 | HSPB5crystallin, alpha BAffinity Capture-Western
Two-hybrid		BioGRID11700327 
CRYBB2CCA2 | CRYB2 | CRYB2A | D22S665crystallin, beta B2Affinity Capture-Western
Two-hybrid		BioGRID11700327 
CRYGCCCL | CRYG3crystallin, gamma CAffinity Capture-Western
Two-hybrid		BioGRID11700327 
CRYZDKFZp779E0834 | FLJ41475crystallin, zeta (quinone reductase)-HPRD11672428 
CS-citrate synthase-HPRD11377425 
HSPB1CMT2F | DKFZp586P1322 | HMN2B | HS.76067 | HSP27 | HSP28 | Hsp25 | SRP27heat shock 27kDa protein 1-HPRD,BioGRID11700327 
LALBAMGC138521 | MGC138523lactalbumin, alpha--HPRD,BioGRID9346914 
MIPAQP0 | LIM1 | MIP26 | MP26major intrinsic protein of lens fiber-HPRD,BioGRID8910261 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GAUSSMANN MLL AF4 FUSION TARGETS A UP 191128All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE DN 8759All SZGR 2.0 genes in this pathway
LIU SMARCA4 TARGETS 6439All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 10767All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE UP 3624All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS POLYSOMY7 UP 7950All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 12683All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway